Results 71 to 80 of about 1,628,849 (334)
, 2017 This paper evaluates the impact of various event extraction systems on automatic pathway curation using the popular mTOR pathway. We quantify the impact of training data sets as well as different machine learning classifiers and show that some improve ...
Kusa, Wojciech, Spranger, Michael
core +1 more source
Fostering open science practice through recognising and rewarding research data management and curation skills [PDF]
, 2016 In a bid to improve research integrity, drive innovation, increase knowledge and to maximize public investment, researchers are increasingly under pressure to work in a more open and transparent way.
Davidson, Joy
core +1 more source
Data curations by the Dutch Data Curation Service [PDF]
, 2014 CLARIN Annual Conference, 24 oktober ...
Heuvel, H. van den +3 more
openaire
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Extending the Research Data Toolkit: Data Curation Primers
International Journal of Digital Curation, 2020 Niche and proprietary data formats used in cutting-edge research and technology have specific curation considerations and challenges. The increased demand for subject liaisons, library archivists, and digital curators to curate this variety of data types
Cynthia Hudson-Vitale +7 more
doaj +1 more source
IRTA Data Curation Checklist for Curators
, 2023 The Data Curation Checklist for curators is a practical guide for data curators to ensure that all datasets submitted to multidisciplinary repositories are consistent to be shared and reproduced following the FAIR practices. This work document follows the data curation best practices from DCN CURATED Steps (produced by Data Curation Network).
Reverté, Carmen, Bonay Giner, Enric
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
D3.2 Cost Concept Model and Gateway Specification [PDF]
, 2014 This document introduces a Framework supporting the implementation of a cost concept model against which current and future cost models for curating digital assets can be benchmarked.
Ashley, Kevin +10 more
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source