Results 181 to 190 of about 26,063,590 (386)
ASSESSING COMPLIENCE WITH CORPORATE GOVERNANCEPRINCIPLES IN CASE OF ROMANIAN FINANCIAL INVESTMENT COMPANIES [PDF]
Corporate governance includes structures that combine relationshipsbetween parties who invest resources and persons that monitor and manage businesses.These relationships are both formal, defined by rules and regulations and informal,materialized in ...
Ovidiu Spatacean, Tatiana Danescu
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Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Governing Fiscal Commons in the Enlarged EU [PDF]
This study explores the achievements of the acceding countries in the sphere of procedural fiscal rules (labeled as fiscal governance). The primary goal is to answer two questions: what is the current state of fiscal governance in the “novice” EU ...
Martin Gregor
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Open Data Initiatives and Governance in Burkina Faso: Promoting Transparency and Accountability
, 2004 Alassane Ouédraogo +2 more
openalex +1 more source
WRI's Governance Strategy, 2016-2020 [PDF]
, 2016 Transparent, effective, accountable governance is critical to ensuring that development benefits people and the planet. The Governance Center of Excellence works with civil society, governments, development agencies, businesses, and other institutions to
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source