Results 61 to 70 of about 4,706,789 (286)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A missing dimension in measures of vaccination impacts [PDF]

, 2014
Immunological protection, acquired from either natural infection or vaccination, varies among hosts, reflecting underlying biological variation and affecting population-level protection.
AE Barskey, Andrew R. Wargo, Antonio Coutinho, Carlota Rebelo, CJ Struchiner, DL Smith, F Ben-Ami, G Dwyer, Gael Kurath, Glenn F. Rall, Graham F. Medley, HA Druett, IM Longini Jr, M. Gabriela M. Gomes, Marc Lipsitch, ME Halloran, MGM Gomes, MP Zwart, P Aaby, PG Smith, RB Hornick, WA Furumoto, WA Furumoto   +22 more
core   +9 more sources

Study on the Corrosion Behavior and Mechanism of Supersonic Flame Sprayed C276 Coating in Simulated Seawater Environment

Metals
In this study, a Hastelloy C276 coating was fabricated on the surface of Q345B steel using high-velocity oxy-fuel (HVOF) spraying technology, and the corrosion behavior and mechanism of the coating in a simulated seawater environment were investigated ...
Long Yan, Ping Liang, Zengyao Chen, Hongchi Ma, Zhong Li, Cuiwei Du, Zhiyong Liu   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Data protection and the legitimate interest of data controllers: much ado about nothing or the winter of rights? [PDF]

, 2014
EU data protection law is in a process of reform to meet the challenges of the modern economy and rapid technological developments. This study analyses the legitimate interest of data controllers as a legal basis for processing personal data under both ...
Ferretti, F
core  

The promotion of data sharing in pharmacoepidemiology [PDF]

, 2014
This article addresses the role of pharmacoepidemiology in patient safety and the crucial role of data sharing in ensuring that such activities occur. Against the backdrop of proposed reforms of European data protection legislation, it considers whether ...
Sethi, Nayha
core   +1 more source

Rapid screening of the stability of polyacrylamide-based hydrogel coatings via droplet microarray analysis and interpretable machine learning

npj Materials Degradation
The unsatisfactory stability of hydrogel coatings hinders their functional and service performance. Until now, the development of high-performance hydrogel coatings largely relies on the intuition and prior experience of researchers. Machine learning, as
Jingzhi Yang, Yami Ran, Yuting Jin, Annan Kong, Mingyue Zhang, Lingwei Ma, Dawei Zhang   +6 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Deep learning accelerated the discovery of multi‐principal element alloys with various strength‐toughness trade‐offs

Materials Genome Engineering Advances
Machine learning has significantly enhanced the efficiency of multi‐principal element alloys (MPEAs) development. Nonetheless, despite its potential, the rapid discovery of MPEAs with various strength‐toughness trade‐offs remains a largely unexplored ...
Chunhui Fan, Hong Luo, Qiancheng Zhao, Xuefei Wang, Hongxu Cheng, Yue Chang   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source