Results 91 to 100 of about 394,926 (289)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Data Protection Impact Assessment Indicators in Protecting Consumer Personal Data on  E-commerce Platforms

Efforts to protect consumers\u27 personal data on e-commerce platforms can be carried out by conducting a Data Protection Impact Assessment. This article discusses the indicators of the execution of Data Protection Impact Assessment by pivoting on the ...
Tegar Islami Putra, Nurul Fibrianti, Mohammad Raziq Fakhrullah   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Understanding climate risks to world cultural heritage: a systematic analysis and assessment framework for the case of Spain

Heritage Science
Understanding the spatial distribution of world cultural heritage in its present-day geographical context is the foundation for the identification of and subsequent protection from key threats and vulnerabilities, particularly those arising from ...
Haisheng Hu, Richard J. Hewitt
doaj   +1 more source

Hazard identification and occupational risk management of a tractor driver at an agricultural production [PDF]

BIO Web of Conferences
The profession of an agricultural tractor driver is one of the most common professions in agriculture. There is a high level of occupational injury rates among machinists and drivers of vehicles, which is associated with dangerous and difficult working ...
Staseva Elena, Kuzheleva Marina, Pushenko Sergey   +2 more
doaj   +1 more source

An Adapted Data Protection Impact Assessment Tool

, 2021
The significance of Data Protection Impact Assessments (DPIA) increased with the introduction of the General Data Protection Regulation (GDPR) in the EU which obliges companies to conduct a DPIA.
Zaugg, Esther
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A Review of Cyber-security Measuring and Assessment Methods for Modern Enterprises

JOIV: International Journal on Informatics Visualization, 2019
Regarding the huge spread of technology among individuals and enterprises, technologies and electronic communications  become one of the most important pillars of the operation of small and large enterprises alike, and the source of education and ...
Said F. Aboelfotoh, Noha A. Hikal
doaj   +1 more source