Results 101 to 110 of about 397,305 (289)

Hazard identification and occupational risk management of a tractor driver at an agricultural production [PDF]

BIO Web of Conferences
The profession of an agricultural tractor driver is one of the most common professions in agriculture. There is a high level of occupational injury rates among machinists and drivers of vehicles, which is associated with dangerous and difficult working ...
Staseva Elena, Kuzheleva Marina, Pushenko Sergey   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Towards a method for data protection impact assessment : making sense of GDPR requirements [PDF]

, 2019
This policy brief lays the foundations for a method for data protection impact assessment (DPIA) in the European Union (EU). First, as a prerequisite, it proposes a generic method for impact assessment, which is intended to be used – when tailored to the
Kloza, DariuszUGent8020037647479768211442720000-0003-0819-81305592669d-e5b8-11eb-9363-a36b2b93c958, Vazquez Maymir, Sergi, Van Dijk, Niels, Casiraghi, Simone, Kloza, Dariusz, Roda, Sara, Tanas, Alessia, Konstantinou, Ioulia   +7 more
core   +1 more source

A Review of Cyber-security Measuring and Assessment Methods for Modern Enterprises

JOIV: International Journal on Informatics Visualization, 2019
Regarding the huge spread of technology among individuals and enterprises, technologies and electronic communications  become one of the most important pillars of the operation of small and large enterprises alike, and the source of education and ...
Said F. Aboelfotoh, Noha A. Hikal
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

THE EFFECT OF PUBLIC PARTICIPATION IN THE PROCEDURE OF ENVIRONMENTAL IMPACT ASSESSMENT ON THE DEVELOPMENT OF INFRASTRUCTURE INVESTMENTS

Economics and Environment, 2016
Economic development is a long-term process, and faces the idea of sustainable development. Development of the infrastructure investments is one of the most important elements which determinate economic growth.
Beata Gładkowska-Chocian
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Life-cycle assessment of buildings: a Review [PDF]

, 2009
Life-Cycle Assessment (LCA) is one of various management tools for evaluating environmental concerns. This paper reviews LCA from a buildings perspective.
Menzies, Gillian Frances, Banfill, Phillip Frank Gower, Khasreen, Mohamad Monkiz, Mohamad Monkiz Khasreen, Phillip F. G. Banfill, Gillian F. Menzies   +5 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source