Results 81 to 90 of about 417,699 (215)

CONTU’s doctrinal errors and their privacy implications: from copyright law to personal data protection in AI regulation

Теорія і практика інтелектуальної власності
This article critically analyses the doctrinal origins of the contemporary crisis in AI regulation. Examining the U.S. National Commission on New Technological Uses of Copyrighted Works (CONTU, 1974–1978), it argues that current attempts to apply ...
Volodymyr Karpunets
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Environmental Impact Assessment of the Patuakhali Town Protection Embankment, Bangladesh

Journal of Agroforestry and Environment
Environmental impact assessment provides a systematic basis for identifying the beneficial and adverse consequences of development projects and formulating measures to manage those consequences.
Md Afjal Hossain, Md. Hamidul Islam, Sanjit Kumar Mondal   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

DEVELOPMENT OF A METHOD FOR ANALYZING CYBERSECURITY RISKS USING THE EXAMPLE OF CRITICAL FACILITIES OF A TRANSPORT COMPANY

Шәкәрім университетінің хабаршысы: Техника ғылымдар
This study describes a comprehensive methodology for analyzing cybersecurity risks in critical information systems of a transport company, with an emphasis on Supervisory Control And Data Acquisition (SCADA) systems, transport management platforms, and ...
A. Nurusheva, D. Satybaldina, A. K. Shaikhanova, A. Kussainov   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Waiving the consent requirement to mitigate bias in observational precision medicine research

International Journal for Equity in Health
Consent bias is a type of selection bias in biomedical research where those consenting to the research differ systematically from those not consenting.
Ruifeng Song
doaj   +1 more source

Modeling an Industrial Distribution Network with Significant Photovoltaic Integration Using ATP-EMTP

Energies
This article presents an analysis of the impact of photovoltaic (PV) sources on the effectiveness and selectivity of earth fault protection in a 6 kV industrial distribution network. Simulations were conducted in the ATP-EMTP environment using a model of
Katarzyna Nowińska, Krzysztof Kuliński
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source