Results 101 to 110 of about 28,511,988 (353)

Data Science and Prediction [PDF]

SSRN Electronic Journal, 2012
Big data promises automated actionable knowledge creation and predictive models for use by both humans and computers.
openaire   +3 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

When Quantum Computation Meets Data Science: Making Data Science Quantum

Harvard Data Science Review, 2022
Yazhen Wang
doaj   +1 more source

Enabling data‐driven collaborative and reproducible environmental synthesis science

Methods in Ecology and Evolution
This manuscript shares the lessons learned from providing scientific computing support to over 600 researchers and discipline experts, helping them develop reproducible and scalable analytical workflows to process large amounts of heterogeneous data ...
Julien Brun, Nicholas J. Lyon, Angel Chen, Ingrid Slette, Gabriel De La Rosa, Jennifer E. Caselle, Frank W. Davis, Martha R. Downs   +7 more
doaj   +1 more source

INTRODUCTION TO DATA SCIENCE

, 2023
If you want to manipulate data successfully, you need tools to do it, which means you need computer programming skills and some understanding of algorithms and data structures. If you want to manipulate data efficiently, you need tools to do it. Often there is an additional requirement that must be met. Data science always emphasizes data itself as the
Dr. Sushil Dohare, Dr. V SelvaKumar, Sachin Raval, Dr. Sumegh Shrikant Tharewal   +3 more
openaire   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Shared data science infrastructure for genomics data

BMC Bioinformatics, 2019
Background Creating a scalable computational infrastructure to analyze the wealth of information contained in data repositories is difficult due to significant barriers in organizing, extracting and analyzing relevant data.
Hamid Bagheri, Usha Muppirala, Rick E. Masonbrink, Andrew J. Severin, Hridesh Rajan   +4 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source