Results 81 to 90 of about 12,937,092 (315)

Graphing of E-Science Data with varying user requirements [PDF]

open access: yes, 2011
Based on our experience in the Swiss Experiment, exploring experimental, scientific data is often done in a visual way. Starting from a global overview the users are zooming in on interesting events.
Aly, Robin, Wombacher, Andreas
core   +2 more sources

Intersections between Information Science and Big Data

open access: yesEm Questão
The aim of this work is to identify the interrelationships between Big Data and Information Science based on a literature review of scientific communications indexed in the Scopus and Web of Science databases ...
Joel Perozo-Vasquez   +2 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Big Data of Materials Science - Critical Role of the Descriptor

open access: yes, 2015
Statistical learning of materials properties or functions so far starts with a largely silent, non-challenged step: the choice of the set of descriptive parameters (termed descriptor).
Draxl, Claudia   +4 more
core   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Enabling data‐driven collaborative and reproducible environmental synthesis science

open access: yesMethods in Ecology and Evolution
This manuscript shares the lessons learned from providing scientific computing support to over 600 researchers and discipline experts, helping them develop reproducible and scalable analytical workflows to process large amounts of heterogeneous data ...
Julien Brun   +7 more
doaj   +1 more source

INTRODUCTION TO DATA SCIENCE

open access: yes, 2023
If you want to manipulate data successfully, you need tools to do it, which means you need computer programming skills and some understanding of algorithms and data structures. If you want to manipulate data efficiently, you need tools to do it. Often there is an additional requirement that must be met. Data science always emphasizes data itself as the
Dr. Sushil Dohare   +3 more
openaire   +3 more sources

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