Results 81 to 90 of about 28,511,988 (353)

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Head CT deep learning model is highly accurate for early infarct estimation

Scientific Reports, 2023
Non-contrast head CT (NCCT) is extremely insensitive for early ( 0.98). When this 150 CT test set was expanded to include a total of 364 CT scans with a more heterogeneous distribution of infarct locations (94 stroke-negative, 270 stroke-positive mixed ...
Romane Gauriau, Bernardo C. Bizzo, Donnella S. Comeau, James M. Hillis, Christopher P. Bridge, John K. Chin, Jayashri Pawar, Ali Pourvaziri, Ivana Sesic, Elshaimaa Sharaf, Jinjin Cao, Flavia T. C. Noro, Walter F. Wiggins, M. Travis Caton, Felipe Kitamura, Keith J. Dreyer, John F. Kalafut, Katherine P. Andriole, Stuart R. Pomerantz, Ramon G. Gonzalez, Michael H. Lev   +20 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science

, 2018
We present QIIME 2, an open-source microbiome data science platform accessible to users spanning the microbiome research ecosystem, from scientists and engineers to clinicians and policy makers.
Evan Bolyen, J. Rideout, Matthew R. Dillon, Nicholas A. Bokulich, C. Abnet, Gabriel A. Al-Ghalith, Harriet Alexander, Harriet Alexander, E. Alm, Manimozhiyan Arumugam, F. Asnicar, Yang Bai, J. Bisanz, K. Bittinger, A. Brejnrod, Colin J. Brislawn, C. T. Brown, B. Callahan, A. Caraballo-Rodríguez, John H. Chase, Emily K. Cope, R. R. Silva, P. Dorrestein, G. Douglas, D. Durall, C. Duvallet, C. Edwardson, Madeleine Ernst, M. Estaki, Jennifer T. Fouquier, J. Gauglitz, D. Gibson, Antonio Gonzalez, Kestrel Gorlick, Jiarong Guo, Benjamin M Hillmann, S. Holmes, H. Holste, C. Huttenhower, C. Huttenhower, G. Huttley, Stefan Janssen, Alan K. Jarmusch, Lingjing Jiang, Benjamin D. Kaehler, K. Kang, K. Kang, Christopher R. Keefe, P. Keim, S. Kelley, D. Knights, I. Koester, I. Koester, T. Kosciólek, Jorden Kreps, M. Langille, Joslynn S. Lee, R. Ley, R. Ley, Yong-xin Liu, E. Loftfield, C. Lozupone, Massoud Maher, C. Marotz, Bryan D. Martin, Daniel McDonald, L. McIver, L. McIver, A. Melnik, J. Metcalf, S. C. Morgan, James T. Morton, Ahmad Turan Naimey, Jose A Navas-Molina, Jose A Navas-Molina, Louis-Félix Nothias, Stephanie B. Orchanian, Talima R. Pearson, Samuel L. Peoples, Samuel L. Peoples, D. Petráš, M. Preuss, E. Pruesse, Lasse Buur Rasmussen, A. Rivers, Ii Michael S Robeson, P. Rosenthal, N. Segata, Michael Shaffer, A. Shiffer, R. Sinha, Se Jin Song, J. Spear, Austin D. Swafford, Luke R. Thompson, Luke R. Thompson, P. Torres, Pauline Trinh, A. Tripathi, A. Tripathi, P. Turnbaugh, Sabah Ul-Hasan, J. J. Hooft, Fernando Vargas, Y. Vázquez-Baeza, E. Vogtmann, Max von Hippel, William Walters, Yunhu Wan, Mingxun Wang, Jonathan Warren, Kyle C. Weber, Kyle C. Weber, Chase Williamson, A. Willis, Z. Xu, Jesse R. Zaneveld, Yilong Zhang, R. Knight, J. Caporaso   +119 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Biological and technical complexities in analyzing extracellular vesicle immune interactions in B‐cell malignancies

FEBS Letters, EarlyView.
Extracellular vesicles (EVs) mediate intercellular communication in tumor immune microenvironments. However, their role in B‐cell malignancies remains poorly defined, owing to biological complexity and technical challenges in EV isolation and analysis.
Daniel Bachurski, Michael Hallek
wiley   +1 more source

Data Science in 2020: Computing, Curricula, and Challenges for the Next 10 Years

Journal of Statistics and Data Science Education, 2021
In the past 10 years, new data science courses and programs have proliferated at the collegiate level. As faculty and administrators enter the race to provide data science training and attract new students, the road map for teaching data science remains ...
Aimee Schwab-McCoy, Catherine M. Baker, Rebecca E. Gasper   +2 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source