Results 91 to 100 of about 25,618,778 (303)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Analysis of beam spot deviation considering vibration of components in optical pickup
Mechanical Engineering Journal, 2018 An optical disc drive uses an optical pickup to read and write data by focusing a laser beam on the data plane of a rotating disc. The pickup is required to keep the beam spot on the current track.
Manabu OCHI +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
A Study of Key Management for Encrypted Storage in Storage Area Network [PDF]
As secure storage becomes more pervasive throughout the enterprise, the focus quickly moves from implementing encrypting storage devices to establishing effective and secure key management policies.
Hai Xin LU
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Optimal Peer-to-Peer Energy Sharing Between Prosumers Using Hydrokinetic, Diesel Generator and Pumped Hydro Storage [PDF]
, 2019 Published ArticleIn this paper, an optimal Peer-to-Peer energy sharing model between two small prosumers is developed and simulated in the south African context.
Kusakana, Kanzumba
core +1 more source
IEEE AccessTo address the challenges of efficient intelligent retrieval and cross-modal analysis brought by the surge in audio-video data, this study proposes an intelligent retrieval method for audio-video content based on deep learning techniques, aimed at ...
Maojin Sun
doaj +1 more source
Advances in Materials Science and Engineering, 2015 Exchange coupled composite bit patterned media (ECC-BPM) are one candidate to solve the trilemma issues, overcome superparamagnetic limitations, and obtain ultrahigh areal density.
Warunee Tipcharoen +2 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source