Results 101 to 110 of about 3,300,037 (290)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Analysis of beam spot deviation considering vibration of components in optical pickup
Mechanical Engineering Journal, 2018 An optical disc drive uses an optical pickup to read and write data by focusing a laser beam on the data plane of a rotating disc. The pickup is required to keep the beam spot on the current track.
Manabu OCHI +2 more
doaj +1 more source
The Review of Laser Engineering, 2004 In the last several years, the research and development of high capacity information storage using holographic technology has been actively carried out by many researchers. This has been driven by several factors. First, the availability and performance of components for drives have changed dramatically.
Manabu YAMAMOTO, Hitoshi SAKURABU
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Advances in Materials Science and Engineering, 2015 Exchange coupled composite bit patterned media (ECC-BPM) are one candidate to solve the trilemma issues, overcome superparamagnetic limitations, and obtain ultrahigh areal density.
Warunee Tipcharoen +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
IEEE AccessTo address the challenges of efficient intelligent retrieval and cross-modal analysis brought by the surge in audio-video data, this study proposes an intelligent retrieval method for audio-video content based on deep learning techniques, aimed at ...
Maojin Sun
doaj +1 more source
Optical data storage using orthogonal wavelength multiplexed volume holograms [PDF]
, 1992 We propose a volume holographic data storage scheme that employs counterpropagating reference and image beams and wavelength multiplexing for page differentation. This method is compared with that based on angular multiplexing. A reduction in holographic
Leyva, Victor +2 more
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source