Results 71 to 80 of about 1,372,066 (309)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Data Visualization

, 2022
Sviluppo web in Digital Humanities e Patrimonio Culturale a.a. 2021/2022 Il ciclo di seminari Sviluppo web per il corso tenuto dalla Prof.ssa Francesca Tomasi Digital Humanities e Patrimonio Culturale (1)(LM) ha l'obiettivo di illustrare alcune delle funzionalità base e avanzate di Bootstrap e di GitHub.
openaire   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Visual evaluation of graph representation learning based on the presentation of community structures

Visual Informatics
Various graph representation learning models convert graph nodes into vectors using techniques like matrix factorization, random walk, and deep learning. However, choosing the right method for different tasks can be challenging.
Yong Zhang, Lihong Cai, Yuhua Liu, Yize Li, Songyue Li, Yuming Ma, Yuwei Meng, Zhiguang Zhou   +7 more
doaj  

Concept transfer of synaptic diversity from biological to artificial neural networks

Nature Communications
Recent developments in artificial neural networks have drawn inspiration from biological neural networks, leveraging the concept of the artificial neuron to model the learning abilities of biological nerve cells.
Martin Hofmann, Moritz Franz Peter Becker, Christian Tetzlaff, Patrick Mäder   +3 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

A kinase to cytokine explorer to identify molecular regulators and potential therapeutic opportunities

eLife
Cytokines and chemokines are secreted proteins that regulate various biological processes, such as inflammation, immune response, and cell differentiation. Therefore, disruption of signaling pathways involving these proteins has been linked to a range of
Marina Chan, Yuqi Kang, Shannon Osborne, Michael Zager, Taranjit S Gujral   +4 more
doaj   +1 more source

Accurate and Computational: A review of color reproduction in Full-color 3D printing

Materials & Design, 2021
As functional 3D printing becomes more popular with industrial manufacturing applications, it is time to start discussing high-fidelity appearance reproduction of 3D objects, particularly in faithful colors.
Jiangping Yuan, Guangxue Chen, Hua Li, Hartmut Prautzsch, Kaida Xiao   +4 more
doaj  

Providing Library Support for Interactive Scientific and Biomedical Visualizations with Tableau

Journal of eScience Librarianship, 2018
Developing effective visualizations is crucial for understanding and communicating data in a variety of contexts. Tableau is an easy-to-use tool for creating customized, interactive visualizations.
Lisa M. Federer, Douglas J. Joubert
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source