Results 71 to 80 of about 2,842,615 (341)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Multi Visualization and Dynamic Query for Effective Exploration of Semantic Data [PDF]

, 2009
Semantic formalisms represent content in a uniform way according to ontologies. This enables manipulation and reasoning via automated means (e.g. Semantic Web services), but limits the user’s ability to explore the semantic data from a point of view that
B. Shneiderman, B.B. Bederson, D. Petrelli, E. Oren, G. Stasko, H. Stuckenschmidt, K.W. Tu, M. Hearst, M. Hearst, M.C. Schraefel, M.C. Schraefel, P. Mutton, R. Bhagdev, R. Bhagdev, R. White, S. Card, T. Aditya, V.T. Thai   +17 more
core   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Investigating the Performance of Retrieval-Augmented Generation and Domain-Specific Fine-Tuning for the Development of AI-Driven Knowledge-Based Systems

Machine Learning and Knowledge Extraction
Generative large language models (LLMs) have revolutionized the development of knowledge-based systems, enabling new possibilities in applications like ChatGPT, Bing, and Gemini.
Róbert Lakatos, Péter Pollner, András Hajdu, Tamás Joó   +3 more
doaj   +1 more source

Virtual Reality Visualization by CAVE with VFIVE and VTK

, 2005
The CAVE-type virtual reality (VR) system was introduced for scientific visualization of large scale data in the plasma simulation community about a decade ago.
Kageyama, Akira, Kusano, Kanya, Ohno, Nobuaki   +2 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Annotated Pap cell images and smear slices for cell classification

Scientific Data
Machine learning-based systems have become instrumental in augmenting global efforts to combat cervical cancer. A burgeoning area of research focuses on leveraging artificial intelligence to enhance the cervical screening process, primarily through the ...
David Kupas, Andras Hajdu, Ilona Kovacs, Zoltan Hargitai, Zita Szombathy, Balazs Harangi   +5 more
doaj   +1 more source

Narrative Visualization: Sharing Insights into Complex Data [PDF]

, 2012
This paper is a reflection on the emerging genre of narrative visualization, a creative response to the need to share complex data engagingly with the public.
Dove, G., Jones, S.
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source