Results 61 to 70 of about 3,107,135 (285)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Interactive Data Exploration of Distributed Raw Files: A Systematic Mapping Study
IEEE Access, 2019 When exploring big amounts of data without a clear target, providing an interactive experience becomes really difficult, since this tentative inspection usually defeats any early decision on data structures or indexing strategies.
Alejandro Alvarez-Ayllon +2 more
doaj +1 more source
Drive Video Analysis for the Detection of Traffic Near-Miss Incidents
, 2018 Because of their recent introduction, self-driving cars and advanced driver assistance system (ADAS) equipped vehicles have had little opportunity to learn, the dangerous traffic (including near-miss incident) scenarios that provide normal drivers with ...
Kataoka, Hirokatsu +4 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Anatomy of Blockchain Database Systems Blockchain Database System
, 2023 Blockchains are here for more than tenfifteen years and currently, we are adopting the blockchain techniques in databases, and vice-versa. Example, A typical blockchain data structures, such as cryptographically-linked blocks and Merkle trees, have been interspersed. Into verifiable databases.
Morey, Aditi, Akanksha Kulkarni
openaire +1 more source
Study on evaluation of International Science and Technology Cooperation Project (ISTCP) in China [PDF]
, 2006 This paper presents an overview of evaluation of ISTCP in China. We discuss briefly the history of evaluation and the strengths and weaknesses of different assessment systems.
Cheng, Su +4 more
core
Event Indexing Systems for Efficient Selection and Analysis of HERA Data
, 2001 The design and implementation of two software systems introduced to improve the efficiency of offline analysis of event data taken with the ZEUS Detector at the HERA electron-proton collider at DESY are presented.
Bauerdick, L. A. T. +4 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source