Results 91 to 100 of about 287,498 (311)
A Theory of Spatio-temporal Database Queries [PDF]
, 2002 We address a fundamental question concerning spatio-temporal database systems: "What are exactly spatio-temporal queries?" We define spatio-temporal queries to be computable mappings that are also generic, meaning that the result of a query may only depend to a limited extent on the actual internal representation of the spatio-temporal data. Genericity
Floris Geerts +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Declarative graph querying in practice and theory [PDF]
, 2017 With the recent resurgence of interest in graph data man- agement, there has been a flurry of research on the design and engineering of graph query languages.
Orlando, Salvatore +8 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Implementing imperfect information in fuzzy databases [PDF]
, 2005 Information in real-world applications is often vague, imprecise and uncertain. Ignoring the inherent imperfect nature of real-world will undoubtedly introduce some deformation of human perception of real-world and may eliminate several substantial ...
Naija, Y. +5 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
HIBROWSE for Hotels: bridging the gap between user and system views of a database [PDF]
, 1994 Database theory and technology has traditionally been concerned with issues such as consistency and efficiency rather than usability. This has led to interaction styles which focus on the structure of the database, which is system-based, rather than the ...
Pollitt, A.S., Ellis, G., Finlay, J.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Object-oriented modeling and design of database federations [PDF]
We describe a logical architecture and a general semantic framework for precise specification of so-called database federations. A database federation provides for tight coupling of a collection of heterogeneous component databases into a global ...
Balsters, H.
core +1 more source
A Deductive Object-Oriented Database System for Situated Inference in Law [PDF]
, 1996 Deductive Object-Oriented Databases and Situation Theory are two important areas of research in the fields of databases and of linguistics. AI and law is a new field attracting both AI researchers and legal practitioners. Our research brings together the
Wong, Stephen, Tojo, Satoshi
core +1 more source