Results 101 to 110 of about 287,498 (311)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A database for water transitions from experiment and theory [PDF]
, 2006 Water is molecule number 1 in the HITRAN linelist and the correct treatment of its spectroscopic properties is crucial to the enduring success the database.
Tennyson, Jonathan +1 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Federation views as a basis for querying and updating database federations [PDF]
This paper addresses the problem of how to query and update so-called database federations. A database federation provides for tight coupling of a collection of heterogeneous component databases into a global integrated system.
Brock, E.O. de, Balsters, H.
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Wuzhen pian 悟真篇 also known as “Essay on the [Immediate] Awakening to Truth”, “Chapters on Awakening to Perfection” [PDF]
, 2021 Wuzhen pian (DZ 263.26, j. 26-30 and DZ 1017, j. 18, “Essay on the [Immediate] Awakening to Truth.” Also translated as “Chapters on Awakening to Perfection.” Its preface is dated to 1075, and its postface is dated to 1078) is a seminal Daoist inner ...
Li, Wanmeng
core
Regularity in Vague Intersection Graphs and Vague Line Graphs
Abstract and Applied Analysis, 2014 Fuzzy graph theory is commonly used in computer science applications, particularly in database theory, data mining, neural networks, expert systems, cluster analysis, control theory, and image capturing.
Muhammad Akram +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The exploration of a category theory-based virtual Geometrical product specification system for design and manufacturing [PDF]
In order to ensure quality of products and to facilitate global outsourcing, almost all the so-called “world-class” manufacturing companies nowadays are applying various tools and methods to maintain the consistency of a product’s characteristics ...
Xu, Yuanping
core