Results 111 to 120 of about 287,498 (311)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Applying Database Dependency Theory to Software Engineering [PDF]
, 1992 We describe the use of database dependency theory for investigating software designs. Dependency theory captures some of the essential constraints implicit in a system, and focuses attention on its update properties.
Darrell R. Raymond +2 more
core
Innovative aspects of designing and managing database systems for modern companies in the energy sector [PDF]
E3S Web of ConferencesThe transition to digital channels and maximum digitalization of the business of modern companies in the energy sector dictate the need to improve and develop new approaches to design and database management. The study aims to identify innovative aspects
Alrhaimi Salem Ahmad
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Buddhist Nuns of 4th - 6th century China [PDF]
, 2022 The earliest Buddhist nuns in China lived between the 4th and 6th centuries AD. We have record of their lives from Baochang’s compilation of their biographies in 516 AD.
Lin, Kathy
core
CARTOGRAPHIC APPROACHES FOR STUDY THE MIGRATION OF ARTIFICIAL RADIONUCLIDES
InterCarto. InterGIS, 2013 Stages of creation of an information-cartographical database according to distribution of artificial radionuclides in landscapes are considered in the article.
T. A. Vorobieva +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
New spaces for researching postgraduate Education research in South Africa
South African Journal of Education, 2013 Universities in South Africa during apartheid reflected the racialised politics of the period. This gave rise to divisive descriptors such as 'historically white/black'; 'English/Afrikaans-speaking' institutions and 'Bantustan' universities.
Daisy Pillay, Jenni Karlsson
doaj
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The Quest for Faster Join Algorithms (Invited Talk) [PDF]
Joins are the cornerstone of relational databases. Surprisingly, even after several decades of research in the systems and theory database community, we still lack an understanding of how to design the fastest possible join algorithm.
Deep, Shaleen +3 more
core +1 more source