Results 71 to 80 of about 1,622,308 (337)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Combining Realist approaches and Normalization Process Theory to understand implementation: a systematic review

open access: yesImplementation Science Communications, 2021
Background Realist approaches and Normalization Process Theory (NPT) have both gained significant traction in implementation research over the past 10 years.
Sonia Michelle Dalkin   +3 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Microkinetics of alcohol reforming for H2 production from a FAIR density functional theory database

open access: yesNature Communications, 2018
The production of hydrogen from biomass is of fundamental importance for a sustainable future. Here, the authors present a multiscale method that allows the formulation of scaling relationships and microkinetics of C1-C2 alcohol decomposition based on a ...
Qiang Li   +2 more
doaj   +1 more source

Databases, Doctrine, and Constitutional Criminal Procedure [PDF]

open access: yes, 2010
Over the past twenty years there has been an explosion in the creation, availability, and use of criminal justice databases. Large scale database systems now routinely influence law enforcement decisions ranging from formal determinations to arrest or ...
Murphy, Erin
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Extending the relational model with uncertainty and ignorance [PDF]

open access: yes, 2004
It has been widely recognized that in many real-life database applications there is growing demand to model uncertainty and ignorance. However the relational model does not provide this possibility.
Blok, Henk Ernst   +2 more
core   +1 more source

Efficient Database Generation for Data-driven Security Assessment of Power Systems

open access: yes, 2019
Power system security assessment methods require large datasets of operating points to train or test their performance. As historical data often contain limited number of abnormal situations, simulation data are necessary to accurately determine the ...
Chatzivasileiadis, Spyros   +3 more
core   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

open access: yesMolecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo   +8 more
wiley   +1 more source

Color-Based Image Retrieval Using Proximity Space Theory

open access: yesAlgorithms, 2018
The goal of object retrieval is to rank a set of images by their similarity compared with a query image. Nowadays, content-based image retrieval is a hot research topic, and color features play an important role in this procedure.
Jing Wang   +4 more
doaj   +1 more source

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