Results 91 to 100 of about 542,743 (309)

Domain fusion analysis by applying relational algebra to protein sequence and domain databases

BMC Bioinformatics, 2003
Background Domain fusion analysis is a useful method to predict functionally linked proteins that may be involved in direct protein-protein interactions or in the same metabolic or signaling pathway.
Ikura Mitsuhiko, Truong Kevin
doaj   +1 more source

Opening up connectivity between documents, structures and bioactivity

Beilstein Journal of Organic Chemistry, 2020
Bioscientists reading papers or patents strive to discern the key relationships reported within a document “D“ where a bioactivity “A” with a quantitative result “R” (e.g., an IC50) is reported for chemical structure “C” that modulates (e.g., inhibits) a
Christopher Southan
doaj   +1 more source

ISPIDER Central: an integrated database web-server for proteomics

, 2008
Despite the growing volumes of proteomic data, integration of the underlying results remains problematic owing to differences in formats, data captured, protein accessions and services available from the individual repositories.
Zamboulis, L., Pentony, Melissa M., Poulovassillis, Alexandra, Hubbard, S.J., Orengo, Christine A., Belhajjame, K., Selley, J.N., Orengo, C.A., Côté, Richard, Zamboulis, Lucas, Siepen, Jennifer A., Oliver, Stephen G., Jones, D.T., Goble, C.A., Oliver, S.G., Selley, Julian N., Embury, Suzanne M.; id_orcid, Siepen, J.A., Jones, Philip, Stevens, R., Embury, S.M., Côté, R., Jones, David T., Hubbard, Simon J.; id_orcid, Hermjakob, Henning, Poulovassilis, Alexandra, Jones, P., Goble, Carole A., Paton, N.W., Martin, Nigel, Pentony, M.M., Hermjakob, H., Paton, Norman W.; id_orcid, Belhajjame, Khalid, Stevens, Robert   +34 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines

Genome Medicine, 2017
Background Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as ...
Javier A. Alfaro, Alexandr Ignatchenko, Vladimir Ignatchenko, Ankit Sinha, Paul C. Boutros, Thomas Kislinger   +5 more
doaj   +1 more source

Domain discovery method for topological profile searches in protein structures

, 2004
We describe a method for automated domain discovery for topological profile searches in protein structures. The method is used in a system TOPStructure for fast prediction of CATH classification for protein structures (given as PDB files).
Viksna, J, Juris Viksna, Gilbert, D, Gilleain Torrance, Torrance, G, David Gilbert   +5 more
core  

List of protein databases.

, 2023
Developments in sequencing technologies and the sequencing of an ever-increasing number of genomes have revolutionised studies of biodiversity and organismal evolution.
Emma U. Hammarlund (10966182), Kristian Pietras (84915), Paulina Bolivar (14675341), Florian Jacques (3271500)   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Brief Review of RNA-Protein Interaction Database Resources

Non-Coding RNA, 2017
RNA-protein interactions play critical roles in various biological processes. By collecting and analyzing the RNA-protein interactions and binding sites from experiments and predictions, RNA-protein interaction databases have become an essential resource
Ying Yi, Yue Zhao, Yan Huang, Dong Wang
doaj   +1 more source