Results 81 to 90 of about 542,743 (309)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Large protein databases reveal structural complementarity and functional locality
Nature CommunicationsRecent breakthroughs in protein structure prediction have led to a surge in high-quality 3D models, highlighting the need for efficient computational solutions. In our work, we examine the structural clusters from the AlphaFold Protein Structure Database
Paweł Szczerbiak +5 more
doaj +1 more source
THE APPLICATION OF BIOINFORMATIC METHODS FOR THE ANALYSIS OF PROTEIN TARGETS OF MICROORGANISMS PRODUCING BIOSURFACTANTS [PDF]
Biotechnologia ActaAim. The objective of this study is to identify key protein targets involved in the metabolism, regulation, and transport of biosurfactants. Target selection was based on a comprehensive analysis of biological databases and scientific literature.
Ye.B. Yanvarov +3 more
doaj +1 more source
Bayesian sequence learning for predicting protein cleavage points
, 2005 A challenging problem in data mining is the application of efficient techniques to automatically annotate the vast databases of biological sequence data.
Michael Mayo, Mayo, Michael
core +1 more source
Implementation of Multidimensional Protein Identification Technology and its Application to the Characterization of Protein Complexes in Bakers Yeast [PDF]
, 2006 The analysis of complex polypeptide mixtures poses a central and ubiquitous problem to biochemistry, molecular and cellular biology. Historically the problem has been approached by means of gel electrophoretic separation, coupled to immune-chemistry or ...
Graumann, Johannes
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
An analysis of the Sargasso Sea resource and the consequences for database composition
, 2006 Background: The environmental sequencing of the Sargasso Sea has introduced a huge new resource of genomic information. Unlike the protein sequences held in the current searchable databases, the Sargasso Sea sequences originate from a single marine ...
Cozzetto Domenico +15 more
core +1 more source
Protein- protein interaction network for common DEGs.
, 2023 All disconnected nodes were removed from the network. The sphere represents node (protein encoded by the gene) and the line depicts interaction. The color of the line is representative of the source of evidence for interaction, including text mining ...
Attya Bhatti (4762944) +2 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source