Results 121 to 130 of about 542,743 (309)
dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
BMC Bioinformatics, 2018 Background Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs.
Quanya Liu +4 more
doaj +1 more source
Protein Docking mit weichen Volumenmodellen
, 2003 Neumann S. Soft volume models for protein-protein docking. Bielefeld (Germany): Bielefeld University; 2003.Der Begriff "Protein Docking" beschreibt die Frage, ob und wie zwei gegebene Proteine interagieren, ausgehend von der 3D Struktur.
Neumann, Steffen
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
ProtMiscuity: a database of promiscuous proteins
Database, 2019 Abstract Promiscuous behaviour in proteins and enzymes remains a challenging feature to understand the structure–function relationship. Here we present ProtMiscuity, a manually curated online database of proteins showing catalytic promiscuity.
Ana Julia Velez Rueda +4 more
openaire +3 more sources
Integrative approaches to protein homology search
, 2005 Alam I. Integrative approaches to protein homology search. Bielefeld (Germany): Bielefeld University; 2005.Many methods have been developed to search for homologous members of a protein family in databases, and the reliability of results and conclusions ...
Alam, Intikhab
core
Databases used for protein identification.
, 2012 Databases used for protein identification.
Carolin A. Kolmeder (188319) +9 more
core +1 more source
A machine learning approach to explore the spectra intensity pattern of peptides using tandem mass spectrometry data [PDF]
, 2008 Background: A better understanding of the mechanisms involved in gas-phase fragmentation of peptides is essential for the development of more reliable algorithms for high-throughput protein identification using mass spectrometry (MS).
Cong Zhou +13 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Databases for Protein–Ligand Complexes [PDF]
Acta Crystallographica Section D Biological Crystallography, 1998 Recent advances in experimental techniques have led to an enormous explosion of available data about protein–ligand complexes. To exploit the information that is hidden in these large data, collection tools for managing and accessing huge data collections are needed.
openaire +2 more sources