Results 141 to 150 of about 516,773 (266)

MegaPX: fast and space-efficient peptide assignment method using IBF-based multi-indexing. [PDF]

Bioinformatics
Lutfi A, Holstein T, Andreotti S, Muth T.   +3 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Analysis of molecular targets and mechanisms of Bisphenol F (BPF)-induced non-alcoholic fatty liver disease (NAFLD) based on network toxicology and molecular dynamics. [PDF]

PLoS One
Wang R, Liao Q, Liu X, Sun L, Xia Y.
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Rethinking bioinformatics in liquid-liquid phase separation: data resources, predictive models, and an event-centric perspective. [PDF]

Brief Bioinform
Yuan ZL, Wang B, Chen YL, Huang HQ, Li BH, Zahoor A, Ren L, Du M, Fang RQ, Ning L.   +9 more
europepmc   +1 more source

The PIR protein sequence database [PDF]

Nucleic Acids Research, 1991
W C, Barker, D G, George, L T, Hunt, J S, Garavelli   +3 more
openaire   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Contemporary data-driven innovations in peptide-based therapeutic design. [PDF]

Brief Bioinform
Priyadarsinee L, Kungurtsev V, Kumar V, Chatterjee B, Sastry GN, Murugan NA.   +5 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Protocol for analyzing potential targets of environmental pollutants in human diseases using network toxicology and molecular docking. [PDF]

STAR Protoc
Hong Y, Li J, Zhou J, Wang D, Chen F, Mi Y, Wang Y.   +6 more
europepmc   +1 more source