Results 151 to 160 of about 542,743 (309)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Characterization and exploitation of protein ligand interactions for structure based drug design

, 2009
Most characterised protein-small molecule interactions that display a change in heat capacity (\bigtriangleupCp) occur with a negative \bigtriangleupCp value.
Nilapwar, S.
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

SEPDB: a database of secreted proteins

Database
Abstract Detecting changes in the dynamics of secreted proteins in serum has been a challenge for proteomics. Enter secreted protein database (SEPDB), an integrated secretory proteomics database offering human, mouse and rat secretory proteomics datasets collected from serum, exosomes and cell culture media.
Ruiqing Wang, Chao Ren, Tian Gao, Hao Li 0035, Xiaochen Bo, Dahai Zhu, Dan Zhang, Hebing Chen, Yong Zhang   +8 more
openaire   +2 more sources

Data Mining of Protein Databases

, 2012
Data mining of protein databases poses special challenges because many protein databases are non-relational whereas most data mining and machine learning algorithms assume the input data to be a relational database.
Assi, Christopher
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Hierarchical classification of G-protein-coupled receptors with a PSO/ACO algorithm [PDF]

, 2006
In our previous work we have proposed a hybrid Particle Swarm Optimisation / Ant Colony Optimisation (PSO/ACO) algorithm for discovering classification rules.
Holden, Nicholas, Freitas, Alex A.
core  

Representing and analysing molecular and cellular function in the computer

, 2000
Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Naim, A., Helden, J., Van, Wernisch, L, Eldridge, M, Wodak, S. J., Gilbert, D, Mancuso, R, Helden, JV, Wodak, SJ, Helden, J.,, Wernisch, Lorenz, Naim, A, Wernisch, L., Eldridge, Matthew, van Helden, Jacques, Mancuso, R., Wodak, Shoshana, Eldridge, M., Mancuso, Renato, Gilbert, D.   +19 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Protein structure prediction via deep learning: an in-depth review

Frontiers in Pharmacology
The application of deep learning algorithms in protein structure prediction has greatly influenced drug discovery and development. Accurate protein structures are crucial for understanding biological processes and designing effective therapeutics ...
Yajie Meng, Zhuang Zhang, Chang Zhou, Xianfang Tang, Xinrong Hu, Geng Tian, Jialiang Yang, Yuhua Yao, Yuhua Yao, Yuhua Yao   +9 more
doaj   +1 more source