Results 31 to 40 of about 8,370,207 (250)
The InterPro protein families and domains database: 20 years on
Nucleic Acids Res., 2020 The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites.
Matthias Blum +32 more
semanticscholar +1 more source
KINtaro – protein kinase-like database
BMC Research Notes, 2023 Abstract Objective The superfamily of protein kinases features a common Protein Kinase-like (PKL) three-dimensional fold. Proteins with PKL structure can also possess enzymatic activities other than protein phosphorylation, such as AMPylation or glutamylation. PKL proteins play a vital role in the world of living organisms, contributing to the
Bartosz Baranowski +2 more
openaire +3 more sources
Context-specific interactions in literature-curated protein interaction databases
BMC Genomics, 2018 Background Databases of literature-curated protein-protein interactions (PPIs) are often used to interpret high-throughput interactome mapping studies and estimate error rates.
R. Greg Stacey +3 more
doaj +1 more source
How Far Are We from the Completion of the Human Protein Interactome Reconstruction?
Biomolecules, 2022 After more than fifteen years from the first high-throughput experiments for human protein–protein interaction (PPI) detection, we are still wondering how close the completion of the genome-scale human PPI network reconstruction is, what needs to be ...
Georgios N. Dimitrakopoulos +2 more
doaj +1 more source
Representing and analysing molecular and cellular function in the computer [PDF]
, 2000 Determining the biological function of a myriad of genes, and understanding how they interact to yield a living cell, is the major challenge of the post genome-sequencing era.
Eldridge, M +6 more
core +1 more source
Pfam: the protein families database [PDF]
Nucleic Acids Research, 2013 (Uploaded by Plazi for the Bat Literature Project) Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described.
Finn RD +12 more
openaire +4 more sources
Characterization of Protein Complexes and Subcomplexes in Protein-Protein Interaction Databases
Biochemistry Research International, 2015 The identification and characterization of protein complexes implicated in protein-protein interaction data are crucial to the understanding of the molecular events under normal and abnormal physiological conditions.
Nazar Zaki +2 more
doaj +1 more source
Evaluating deterministic motif significance measures in protein databases
Algorithms for Molecular Biology, 2007 Background Assessing the outcome of motif mining algorithms is an essential task, as the number of reported motifs can be very large. Significance measures play a central role in automatically ranking those motifs, and therefore alleviating the analysis ...
Azevedo Paulo J, Ferreira Pedro
doaj +1 more source
Nucleic Acids Res., 2016 A system-wide understanding of cellular function requires knowledge of all functional interactions between the expressed proteins. The STRING database aims to collect and integrate this information, by consolidating known and predicted protein–protein ...
Damian Szklarczyk +11 more
semanticscholar +1 more source
Network Pharmacology Databases for Traditional Chinese Medicine: Review and Assessment
Frontiers in Pharmacology, 2019 The research field of systems biology has greatly advanced and, as a result, the concept of network pharmacology has been developed. This advancement, in turn, has shifted the paradigm from a “one-target, one-drug” mode to a “network-target, multiple ...
Run-zhi Zhang +3 more
semanticscholar +1 more source