Results 31 to 40 of about 666,912 (235)

UbiProt: a database of ubiquitylated proteins [PDF]

BMC Bioinformatics, 2007
Abstract Background Post-translational protein modification with ubiquitin, or ubiquitylation, is one of the hottest topics in a modern biology due to a dramatic impact on diverse metabolic pathways and involvement in pathogenesis of severe human diseases.
Anastasia S Shorina, Alexander Chernorudskiy, Eugene V Eremin, Alejandro Garcia, Murat R. Gainullin, Ekaterina V Kondratieva   +5 more
openaire   +4 more sources

BacillOndex: An Integrated Data Resource for Systems and Synthetic Biology [PDF]

, 2013
BacillOndex is an extension of the Ondex data integration system, providing a semantically annotated, integrated knowledge base for the model Gram-positive bacterium Bacillus subtilis. This application allows a user to mine a variety of B.
Allenby, Nick, Hallinan, Jennifer S., James, Katherine, Misirli, Goksel, Mullen, Joseph, Pocock, Matthew, Smith, Wendy, Wipat, Anil   +7 more
core   +2 more sources

Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]

, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia, D’Eustachio, Peter, Masci, Anna Maria, Natale, Darren, Ruttenberg, Alan, Shamovsky, Veronica, Smith, Barry, Wu, Cathy   +7 more
core   +4 more sources

DisProt: the Database of Disordered Proteins [PDF]

Nucleic Acids Research, 2007
The Database of Protein Disorder (DisProt) links structure and function information for intrinsically disordered proteins (IDPs). Intrinsically disordered proteins do not form a fixed three-dimensional structure under physiological conditions, either in their entireties or in segments or regions.
A. Keith Dunker, Zoran Obradovic, Tanguy LeGall, Marc S. Cortese, Jake Y. Chen, Agnes Tantos, Beáta Szabó, Justin A. Hamilton, Megan D. Sickmeier, Vladimir Vacic, Peter Tompa, Vladimir N. Uversky, Vladimir N. Uversky   +12 more
openaire   +4 more sources

Integration of Biological Sources: Exploring the Case of Protein Homology [PDF]

, 2011
Data integration is a key issue in the domain of bioin- formatics, which deals with huge amounts of heteroge- neous biological data that grows and changes rapidly.
Boerman, Tjeerd W., Keulen, Maurice van, Severing, Edouard I., Vet, Paul van der   +3 more
core   +2 more sources

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Protein Bioinformatics Databases and Resources [PDF]

, 2010
In the past decades, a variety of publicly available data repositories and resources have been developed to support protein related information management, data-driven hypothesis generation and biological knowledge discovery. However, there is also an increasing confusion for the researchers who are trying to quickly find the appropriate resources to ...
Hongzhan Huang, Cathy H. Wu, Chuming Chen   +2 more
openaire   +4 more sources

AOD: the antioxidant protein database [PDF]

Scientific Reports, 2017
AbstractAn antioxidant is a molecule that can prevent free radicals from causing damages in organisms. The increasing studies on antioxidants calls for a specialized database that is not readily available yet. To this end, in the present study, theAntioxidantDatabase (AOD) was developed to help researchers understand and reveal the biological functions
Pengmian Feng, Hao Lin, Wei Chen, Hui Ding   +3 more
openaire   +4 more sources

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source