Results 51 to 60 of about 542,743 (309)
Genes2Networks: connecting lists of gene symbols using mammalian protein interactions databases
BMC Bioinformatics, 2007 Background In recent years, mammalian protein-protein interaction network databases have been developed. The interactions in these databases are either extracted manually from low-throughput experimental biomedical research literature, extracted ...
Ma'ayan Avi +2 more
doaj +1 more source
An Investigation of Alternatives to Transform Protein Sequence Databases to a Columnar Index Schema
Algorithms, 2021 Mass spectrometers enable identifying proteins in biological samples leading to biomarkers for biological process parameters and diseases. However, bioinformatic evaluation of the mass spectrometer data needs a standardized workflow and system that ...
Roman Zoun +7 more
doaj +1 more source
iProt – A Data Warehouse For Protein Database. [PDF]
, 2007 An integrated database is a vital approach to help biologist to analyze protein data from heterogeneous formats and resources. The iProt (Integrated Protein Data Warehouse) is a pool of protein dataset that provide a comprehensive protein sequence' 3D ...
Jaya, M.I. +2 more
core
Prediction of protein-protein interaction types using association rule based classification
, 2009 This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Park et alBackground: Protein-protein interactions (PPI) can be classified according to their characteristics into, for example obligate or transient ...
José A Reyes +14 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
The Pfam protein families database [PDF]
Nucleic Acids Research, 2007 Pfam is a comprehensive collection of protein domains and families, represented as multiple sequence alignments and as profile hidden Markov models. The current release of Pfam (22.0) contains 9318 protein families. Pfam is now based not only on the UniProtKB sequence database, but also on NCBI GenPept and on sequences from selected metagenomics ...
Robert D. Finn +10 more
openaire +4 more sources
Computational and Structural Biotechnology Journal, 2012 The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in ...
Rajni Verma +2 more
doaj +3 more sources
PrOnto Database : GO term functional dissimilarity inferred from biological data.
Frontiers in Genetics, 2015 Moonlighting proteins are defined by their involvement in multiple, unrelated functions. The computational prediction of such proteins requires a formal method of assessing the similarity of cellular processes, for example, by identifying dissimilar Gene
Charles E Chapple +6 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source