Results 31 to 40 of about 516,773 (266)
BMC Bioinformatics, 2007 Background Each major protein database uses its own conventions when assigning protein identifiers. Resolving the various, potentially unstable, identifiers that refer to identical proteins is a major challenge.
Leinonen Rasko +8 more
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Proteomics: taking over where genomics leaves off
Czech Journal of Genetics and Plant Breeding, 2010 The proteomic studies are simultaneously developed in several directions and significantly influence our notions on the capabilities of biological sciences.
Ritu MAHAJAN, Priyanka GUPTA
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Comparative Assessment of Protein Kinase Inhibitors in Public Databases and in PKIDB
Molecules, 2020 Since the first approval of a protein kinase inhibitor (PKI) by the Food and Drug Administration (FDA) in 2001, 55 new PKIs have reached the market, and many inhibitors are currently being evaluated in clinical trials.
Colin Bournez +6 more
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TOPAZ: asymmetric suffix array neighbourhood search for massive protein databases
BMC Bioinformatics, 2018 Background Protein homology search is an important, yet time-consuming, step in everything from protein annotation to metagenomics. Its application, however, has become increasingly challenging, due to the exponential growth of protein databases.
Alan Medlar, Liisa Holm
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The Pfam protein families database [PDF]
Nucleic Acids Research, 2009 Pfam is a widely used database of protein families and domains. This article describes a set of major updates that we have implemented in the latest release (version 24.0). The most important change is that we now use HMMER3, the latest version of the popular profile hidden Markov model package.
Robert D. Finn +13 more
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MedProDB: A database of Mediator proteins
Computational and Structural Biotechnology Journal, 2021 In the last three decades, the multi-subunit Mediator complex has emerged as the key component of transcriptional regulation of eukaryotic gene expression. Although there were initial hiccups, recent advancements in bioinformatics tools contributed significantly to in-silico prediction and characterization of Mediator subunits from several organisms ...
Rohan Bhardwaj +2 more
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PrOnto Database : GO term functional dissimilarity inferred from biological data.
Frontiers in Genetics, 2015 Moonlighting proteins are defined by their involvement in multiple, unrelated functions. The computational prediction of such proteins requires a formal method of assessing the similarity of cellular processes, for example, by identifying dissimilar Gene
Charles E Chapple +6 more
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An Investigation of Alternatives to Transform Protein Sequence Databases to a Columnar Index Schema
Algorithms, 2021 Mass spectrometers enable identifying proteins in biological samples leading to biomarkers for biological process parameters and diseases. However, bioinformatic evaluation of the mass spectrometer data needs a standardized workflow and system that ...
Roman Zoun +7 more
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The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
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Computational and Structural Biotechnology Journal, 2012 The combination of computational and directed evolution methods has proven a winning strategy for protein engineering. We refer to this approach as computer-aided protein directed evolution (CAPDE) and the review summarizes the recent developments in ...
Rajni Verma +2 more
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