Results 111 to 120 of about 53,590 (235)

Molecular docking of daunorubicin and etoposide drugs against Leishmania donovani: A theoretical study

Journal of Vector Borne Diseases
Background & objectives: The human blood parasite Leishmania donovani causes visceral leishmaniasis or grayish discoloration of the skin (black fever/kala-azar). Antitumor drugs such as daunorubicin and etoposide can help to treat such diseases.
Afnan Mohammed Shakoori, Fatemah Alhakami, Ghadir Sindi, Areej Yahya Alyahyawi, Rasha Abdullah Alhazzaa   +4 more
doaj   +1 more source

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. [PDF]

, 2015
The currently available techniques for the safety evaluation of candidate drugs are usually cost-intensive and time-consuming and are often insufficient to predict human relevant cardiotoxicity.
Bremer, S, Chaudhari, U, Ellis, JK, Gaspar, JA, Hengstler, JG, Hescheler, J, Keun, HC, Louisse, J, Nemade, H, Nguemo, F, Sachinidis, A, Spitkovski, D, Srinivasan, SP, Wagh, V   +13 more
core   +1 more source

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Comparison of Hospital Length of Stay and Supportive Care Utilization Between Patients Treated with CPX-351 and 7+3 for Therapy-Related Acute Myeloid Leukemia or Acute Myeloid Leukemia with Myelodysplasia-Related Changes

ClinicoEconomics and Outcomes Research, 2022
Kwanza Price,1 Zhun Cao,2 Craig Lipkin,2 Deb Profant,1 Scott Robinson2 1Jazz Pharmaceuticals, Palo Alto, CA, USA; 2Premier Inc., Charlotte, NC, USACorrespondence: Deb ProfantJazz Pharmaceuticals, 3170 Porter Dr., Palo Alto, CA, 94304, USATel/Fax +1 971 ...
Price K, Cao Z, Lipkin C, Profant D, Robinson S   +4 more
doaj  

Vasocontractile action of daunorubicin

Journal of Pharmacy and Pharmacology, 1989
Abstract Daunorubicin (35·5–142 μmol L−1) induced in rat aortic strips a contraction with slow onset and a gradual development of tension on which neither phentolamine nor bromophenacyl bromide pretreatment had an effect. The contraction was not altered by removal of the endothelium but it was suppressed in calcium-free solution or by ...
I, Wakabayashi, K, Hatake, E, Kakishita
openaire   +2 more sources

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, Volume 15, Issue 19, 22 May 2026.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

Leukemia cutis as the first manifestation of acute myeloid leukemia

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Florian Winkler, Rosa Brand, Dino Mehic, Felix Tuchmann, Teresa Valero, Johanna Strobl   +5 more
wiley   +1 more source

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML 10 and 12 trials [PDF]

, 2005
Fetal liver tyrosine kinase 3 (FLT3) internal tandem duplications (ITDs) are powerful adverse prognostic indicators for relapse in acute myelold leukemia (AML) but the most efficacious therapy for FLT3/ ITD+ patients is currently unknown.
Burnett, AK, Gale, RE, Hills, R, Kottaridis, PD, Linch, DC, Srirangan, S, Wheatley, K   +6 more
core  

Comprehensive Multispectroscopic and Molecular Docking Investigation of the Anticancer Drug Idarubicin–Bovine Serum Albumin Interaction

Luminescence, Volume 41, Issue 5, May 2026.
The idarubicin–bovine serum albumin interaction was comprehensively investigated using multispectroscopic techniques and molecular docking. The results reveal concentration‐dependent binding, conformational changes in BSA, and static quenching behavior, supported by UV–Vis, fluorescence, FT‐IR, and DLS analyses, confirming stable complex formation ...
Mehmetcan Bilkay, Aytekin Gharanjik, Ahmad Fadhlurrahman Ahmad Hidayat, Saharuddin B. Mohamad, Hayriye Eda Satana Kara   +4 more
wiley   +1 more source

Iodinin (1,6-Dihydroxyphenazine 5,10-Dioxide) from Streptosporangium sp. Induces Apoptosis Selectively in Myeloid Leukemia Cell Lines and Patient Cells

Marine Drugs, 2013
Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a marine actinomycetes bacterium ...
Lars Herfindal, Frode Selheim, Stein Ove Døskeland, Øystein Bruserud, Anders Brunsvik, Kolbjørn Zahlsen, Kristin F. Degnes, Knut Teigen, Håvard Sletta, Gro Gausdal, Lene E. Myhren, Gyrid Nygaard   +11 more
doaj   +1 more source