Results 121 to 130 of about 53,590 (235)

Influence of Perfluorodecalin on Growth of Actinomycetes and Intensification of Streptomycin and Daunorubicin Production by the Genus Streptomyces Kind Bacteria in Submerged Culture

Антибиотики и Химиотерапия, 2020
Addition of perfluorodecalin with gas-transporting function to the liquid medium during submerged cultivation of actinomycetes of the genus Streptomyces resulted in higher intensity and level of the biomass synthesis and increased production of ...
V. M. Bakulin, A. S'. Tumanov, E. A. Martinson, S. G. Litvinec, M. K. Bakulin, V. B. Kalininski   +5 more
doaj  

GATA2 Mutations Predict Poor Prognosis in Transplanted Myeloid Neoplasms

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background GATA binding protein 2 (GATA2) plays a crucial role in the differentiation, proliferation, and maintenance of hematopoietic stem cells (HSCs). GATA2 mutations have been identified in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), but the impact of somatic GATA2 mutations on prognosis remains controversial ...
Xian Zhang, Bingjie Wang, Yujun Dong, Qingya Wang, Qian Wang, Jialin Zhu, Qingyun Wang, Na Han, Yuan Li   +8 more
wiley   +1 more source

Early Detection of Acute and Early‐Onset Cancer Therapy‐Related Cardiac Dysfunction in Children With Cancer Using a Multiparametric Approach: Methodological Aspects of the EARLY Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Cancer therapy‐related cardiac dysfunction (CTRCD) is among the most important adverse effects of treatment of childhood cancer. In the EARLY study (Early detection of acute and early‐onset cARdiovascuLar toxicity in children with cancer using a multiparametric approach), cardiac function in children treated for cancer was monitored
Theodorus W. Kouwenberg, Heynric B. Grotenhuis, Leontien C. M. Kremer, Esmée C. de Baat, Auke Beishuizen, Max M. van Noesel, Livia Kapusta, Rutger A. J. Nievelstein, Birgitta K. Velthuis, Martijn G. Slieker, Tim Leiner, Bianca A. W. Hoeben, Annelies M. C. Mavinkurve‐Groothuis, Elizabeth A. M. Feijen   +13 more
wiley   +1 more source

Gender effects on cytidine analogue metabolism and myelodysplastic syndrome treatment outcomes [PDF]

, 2012
In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine ...
Ania Jankowska, Jaroslaw Maciejewski, Joseph Covey, Kenneth Chan, Kory Engelke, Mikkael Sekeres, Pramod Terse, Quteba Ebrahem, Ramon Tiu, Reda Mahfouz, Tomas Radivoyevitch, Yogen Saunthararajah, Yonghua Ling, Zhenbo Hu   +13 more
core   +1 more source

B‐Lymphoblastic Leukemia With Isolated Central Nervous System Relapse Mimicking a Vestibular Schwannoma

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The central nervous system (CNS) is the most common site of extramedullary relapse in acute lymphoblastic leukemia (ALL). However, the diagnosis may be challenging due to its protean manifestations. A 64‐year‐old male reported right‐sided hearing loss with intermittent bilateral occipitotemporal headaches during a clinic follow‐up for Ph + B ...
Jun Yen Ng, Shivendra T. Lalloo, Samuel Milliken, Mark N. Polizzotto   +3 more
wiley   +1 more source

Hemophagocytic Lymphohistiocytosis Triggered by Legionella pneumophila and SARS‐CoV‐2 Infection in GATA2 Deficiency

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Germline GATA2 deficiency predisposes to bone marrow failure, myeloid neoplasia, and immune dysregulation. The syndrome is often complicated by infection with intracellular pathogens and viruses, autoimmunity, and inflammation. Hemophagocytic lymphohistiocytosis (HLH) is a rare occurrence that can present further management challenges.
Harry Wilson, Nuno Borges, Matthew Collin, Callum Wright   +3 more
wiley   +1 more source

Actionable Pharmacogenomics and Essential Medicines: An Analysis of WHO and African Lists for Safer and Efficacious Drug Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.
The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Janine Scholefield, Collen Masimirembwa   +5 more
wiley   +1 more source

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

Targeting the nuclear export receptor exportin‐1 in acute myeloid leukaemia: From biology to clinical translation

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• XPO1 hyperactivation promotes leukaemogenesis by altering nucleocytoplasmic transport and transcriptional control in acute myeloid leukaemia (AML). • Selinexor and eltanexor show preferential activity in NPM1‐mutated, DEK::NUP214‐positive and SF3B1‐mutated myeloid neoplasms.
Yifan Liu, Xiaoya Yun, Weidong Ding, Suxiao Li, Hui Liu   +4 more
wiley   +1 more source

Nanotechnology Meets Immunotherapy: Crosstalks Against Cancer

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background The convergence of nanotechnology and immunotherapy has ushered in a transformative era in cancer treatment, offering new strategies to overcome pharmacokinetic limitations and immune evasion associated with conventional therapies. While immunotherapy, spanning checkpoint inhibitors, adoptive cell transfer, and cancer vaccines, has ...
Nima Javanmehr, Asal Moazzami Ashtyani, Robabehbeygom Ghafelehbashi, Fateme Mousavi, Hossein Teimouri   +4 more
wiley   +1 more source