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In Silico ADME Methods Used in the Evaluation of Natural Products. [PDF]

open access: yesPharmaceutics
Ancuceanu R   +3 more
europepmc   +1 more source
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Antioxidative and antiapoptosis: Neuroprotective effects of dauricine in Alzheimer's disease models

Life Sciences, 2020
Dauricine has been found that has significant neuroprotective effect on Alzheimer's disease (AD), but the mechanism is unclear, so we further investigated the possible mechanism of dauricine on AD.Cell counting kit-8 (CCK8) was applied to measure the cytotoxicity of dauricine on SH-SY5Y cells that overexpress the Swedish mutant form of human β-amyloid ...
Zhijun Pu, Wei Chen
exaly   +3 more sources

Metabolism of dauricine and identification of its main metabolites

Current Medical Science, 2000
To study the metabolism of dauricine in vivo and in vitro and identify the structure of its main metabolites, urine of rats after drug administration as the samples of dauricine metabolism in vivo was studied. Rat liver S9 fraction was prepared and the oxygenation metabolism system reconstituted to perform phase I reaction of dauricine in vitro.
S, Chen   +4 more
exaly   +3 more sources

Dauricine production in cultured roots of Menispermum dauricum

Phytochemistry, 1994
Abstract Root Cultures of Menispermum dauricum were established from adventitious roots formed on the leaf segments. These roots produce dauricine as a major constituent and the optimum conditions for dauricine production in cultured roots were investigated.
Yukihiro Sugimoto
exaly   +2 more sources

Detection of protein adduction derived from dauricine by alkaline permethylation

Analytical and Bioanalytical Chemistry, 2016
Dauricine is a bisbenzylisoquinoline alkaloid derivative and has shown multiple pharmacological properties. Despite this, our previous study demonstrated that dauricine induced severe lung toxicity in experimental animals. Metabolic activation of dauricine to the corresponding quinone methide intermediate is suggested to play an important role in ...
Dongmei Zhao, Jiang Zheng
exaly   +3 more sources

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