Results 131 to 140 of about 649 (161)
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[First-pass effect of dauricine].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993The first-pass effect of dauricine (Dau) was compared with that of lidocaine (Lid) by measuring the ventricular fibrillation threshold (VFT) and dauricine plasma concentration in rats or rabbits. After forelimb or mesenteric vein (imv) infusion of Dau at a rate of 1 mg.kg-1 x min-1 in rats, the VFT were 1.64-3.17 or 1.60-2.11 V, respectively.
Y T, Gui, Z H, Du, F D, Zeng, C J, Hu
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[Effects of dauricine on slow action potentials in myocardium].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1991The effects of dauricine were examined on the slow action potentials induced by both high K+ (24 mmol/L) or TTX (40 mumol/L) in guinea pig papillary muscles and in sinoatrial node cells of rabbit. Dauricine 40 mumol/L decreased the maximal upstroke velocity (Vmax) of slow action potentials and prolonged the action potential duration at 50 ...
X G, Zong, M X, Jiang
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The American Journal of Chinese Medicine, 2007
Our previous experimental studies showed that dauricine could protect the brain from ischemic damage, but the underlying mechanisms were unknown. In this study, we investigated the effect of dauricine on the changes of the inflammation process induced by ischemia/reperfusion (I/R). After I/R, the enzyme activity of MPO, the expression of ICAM-1 and the
Xiao-Yan, Yang +4 more
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Our previous experimental studies showed that dauricine could protect the brain from ischemic damage, but the underlying mechanisms were unknown. In this study, we investigated the effect of dauricine on the changes of the inflammation process induced by ischemia/reperfusion (I/R). After I/R, the enzyme activity of MPO, the expression of ICAM-1 and the
Xiao-Yan, Yang +4 more
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Identification of Quinone Methide Metabolites of Dauricine in Human Liver Microsomes and in Rat Bile
Chemical Research in Toxicology, 2009Dauricine is one type of the bisbenzyltetrahydroisoquinoline alkaloid derivative with antiarrhythmic effects. Severe liver toxicity was observed in experimental animals treated with analogues of dauricine, which may be caused by covalent binding of reactive metabolite(s) to critical macromolecules in tissues.
Yuya, Wang +3 more
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Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs.
Acta pharmacologica Sinica, 2004To study the combined pharmacokinetic-pharmacodynamic (PK-PD) model of daurisoline and dauricine, and compare their effects on cardiac electrophsiology, blood pressure, and hemodynamics in beagle dogs.The plasma drug concentration was determined by the reversed-phase HPLC method and the effects on cardiac and hemodynamics were recorded by polygraph ...
Shao-Jun, Shi +3 more
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[Quantitative studies on dauricine block of cardiac sodium channels].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1992Quantitative studies on kinetics of dauricine (Dau) blockade of cardiac sodium channels based on the model of gate-related receptor hypothesis were performed by using computer simulation. The time constant of recovery from blocking of Dau at holding potential -80 mV was 9.8 s and increased with membrane potential hyperpolarization, which suggested that
Y J, Wu, D C, Fang
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[Effects of dauricine on the metabolism of arachidonic acid in rat pleural neutrophils].
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990The effects of dauricine (Dau), an isoquinoline alkaloid and anti-arrhythmic agent used in China recently, on the biosynthesis of metabolites of arachidonic acid in rat pleural neutrophils, comparing with dazoxiben, indomethacin and BW-755 c, were studied.
T L, Yue, L, Tong
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Total synthesis of (±)-dauricine
Tetrahedron Letters, 1964Tetsuji Kametani, Keiichiro Fukumoto
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