Results 121 to 130 of about 649 (161)

Inhibitory effects of a bisbenzylisoquinline alkaloid dauricine on HERG potassium channels

Journal of Ethnopharmacology, 2012
The roots of Menispermum dauricum have been widely used for the treatment of inflammation, allergy and arrhythmia in China for a long time. Dauricine (Dau), a bisbenzylisoquinline alkaloid from Menispermum dauricum, mainly contributes to the anti-arrhythmic effect and has received pharmacological attention. Dau can prolong the action potential duration
Jing, Zhao, Yong, Lian, Chunfeng, Lu, Li, Jing, Haitao, Yuan, Shuangqing, Peng   +5 more
exaly   +3 more sources

Inhibitory effects of dauricine on early afterdepolarizations and L-type calcium current

Canadian Journal of Physiology and Pharmacology, 2009
We have previously reported that dauricine exerted antiarrhythmic effects on various experimental arrhythmias. To further clarify its mechanism, the effects of dauricine on action potential duration (APD), early afterdepolarizations (EADs), triangulation, which is defined as the repolarization time from APD at 30% level (APD30) to APD at 90% level ...
Qiang-Ni, Liu, Li, Zhang, Pei-Li, Gong, Xiao-Yan, Yang, Fan-Dian, Zeng   +4 more
exaly   +3 more sources

Protection of dauricine and daurisoline on PC12 cells damaged by glutamate or Aβ25-35

Brain Research
Glutamate (Glu) excitotoxicity and amyloid-β (Aβ) deposition are significant factors in the occurrence and development of Alzheimer's disease (AD). Dauricine and daurisoline are two alkaloid components of Menispermum dauricum DC. that have a protective effect on the nervous system.
Xiao-Han, Ma, Hui, Dai, Song-Yao, Liu, Xiao-Na, Liu, Jing, Zhang, Xue-Lian, Meng   +5 more
exaly   +3 more sources

Dauricine combined with clindamycin inhibits severe pneumonia co-infected by influenza virus H5N1 and Streptococcus pneumoniae in vitro and in vivo through NF-κB signaling pathway

Journal of Pharmacological Sciences, 2018
Dauricine, isolated from Menispermum dauricum, has been widely used for treatment of various diseases, including cardiac ischemia and inflammation-related diseases.
Hui Li, Xin Chen, Shu-Jun Zhou
exaly   +3 more sources

Antagonistic Effect and In Vitro Activity of Dauricine on Glucagon Receptor

Journal of Natural Products, 2022
Abnormal increases in glucagon (GCG) are the primary cause of type II diabetes mellitus. When GCG interacts with a glucagon receptor (GCGR), GCG can increase the blood glucose level. In this paper, a compound that could interfere with the binding of GCG and GCGR to inhibit the increase of blood glucose was investigated.
Li Li, Shuang Dai, Jing-ya Liu, Wei Wu, Qian-xi Zhao, Xin Wang, Na Wang, Zhi-hong Xu   +7 more
openaire   +2 more sources

A sensitive HPLC technique for the quantitation of dauricine

Current Medical Science, 2000
To establish the determination method of dauricine (Dau) concentration in rats' blood and other biological samples, a reverse-phase HPLC method was adopted. Under the given condition, dauricine could be well separated. The retention time (tR) of Dau and its internal standard, daurisoline were 9.2 and 6.1 respectively.
S, Chen, Y, Yang, L, Zhang, X, Pang, Z, Dai, F, Zeng   +5 more
openaire   +2 more sources

Effects of dauricine on the physiologic properties of myocardium

Acta Academiae Medicinae Wuhan, 1984
Effects of dauricine (Dau) on the physiologic properties of myocardium were studied in cat papillary muscles.
G R, Li, D C, Fang, C J, Hu, F H, Lü
openaire   +2 more sources

Pulmonary Toxicity and Metabolic Activation of Dauricine in CD-1 Mice

The Journal of Pharmacology and Experimental Therapeutics, 2010
Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. and has shown promising pharmacological activities with a great potential for clinic use. However, the adverse effects and toxicity of the alkaloid are unfortunately ignored.
Hua, Jin, Jieyu, Dai, Xiaoyan, Chen, Jia, Liu, Dafang, Zhong, Yansong, Gu, Jiang, Zheng   +6 more
openaire   +2 more sources

Dauricine inhibits human pancreatic carcinoma cell proliferation through regulating miRNAs

Molecular Omics, 2021
Abstract Pancreatic cancer is one of the most malignant digestive tract tumors with the worst prognosis. Dauricine (Dau) can inhibit the proliferation of the pancreatic cancer cell line, and has the potential to be used as an adjuvant drug against pancreatic cancer; however, the working mechanism of Dau has not been elucidated.
Ling Jiang, Tianzhu Guo, Ying Jiang, Ping Liu, Yun Bai   +4 more
openaire   +2 more sources

Early Steps of Dauricine Biosynthesis in Cultured Roots ofMenispermum dauricum

Bioscience, Biotechnology, and Biochemistry, 1996
Cultured roots of Menispermum dauricum, a rich source of the bisbenzylisoquinoline alkaloid dauricine (1), were fed with l-[U-(14)C] tyrosine, L-[3-(13)C] tyrosine, and [2-(13)C] tvramine independently, and the incorporation of possible early precursors into 1 was studied.
Y, Sugimoto, S, Uchida, S, Inanaga, Y, Kimura, M, Hashimoto, A, Isogai   +5 more
openaire   +2 more sources