Results 31 to 40 of about 649 (161)

Iron homeostasis imbalance and ferroptosis in brain diseases

MedComm, Volume 4, Issue 4, August 2023., 2023
As neurological diseases that seriously affect the survival and prognosis of patients, stroke and neurodegenerative diseases cause excessive accumulation of brain iron by disturbing the normal mechanism of brain iron absorption and export, accompanied by the outbreak of oxidative stress, which leads to programmed cell death called ferroptosis, and ...
Haining Long, Wangshu Zhu, Liming Wei, Jungong Zhao   +3 more
wiley   +1 more source

Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage

Journal of Nanobiotechnology, 2020
Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, lack of specific targeting to the hemorrhagic ...
Mingxin Li, Guohao Liu, Kaixuan Wang, Lingfeng Wang, Xiang Fu, Lee Yong Lim, Wei Chen, Jingxin Mo   +7 more
doaj   +1 more source

Integrated Network Pharmacology and Proteomic Analyses of Targets and Mechanisms of Jianpi Tianjing Decoction in Treating Vascular Dementia

Evidence-Based Complementary and Alternative Medicine, Volume 2023, Issue 1, 2023., 2023
Background. Vascular dementia (VD), associated with cerebrovascular injury, is characterized by severe cognitive impairment. Jianpi Tianjing Decoction (JTD) has been widely used to treat VD. However, its molecular targets and mechanisms of action in this treatment remain unclear.
Jidan Liu, Juanfen Gong, Jinchao Xu, Mengyuan Fang, Meng Su, Weiguang Li, Yiyi Wu, Yang Hui, Yingchun He, Talha Bin Emran   +9 more
wiley   +1 more source

Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐2

FEBS Open Bio, Volume 12, Issue 1, Page 285-294, January 2022., 2022
Cepharanthine is a natural biscoclaurine alkaloid of plant origin and has recently been demonstrated to have anti‐severe acute respiratory syndrome coronavirus 2 activity. To evaluate the cepharanthine analogues as a potential coronavirus disease 2019 drug, we performed docking simulation and a cell‐based infection assay. From the results, the diphenyl
Atsushi Hijikata, Clara Shionyu‐Mitsuyama, Setsu Nakae, Masafumi Shionyu, Motonori Ota, Shigehiko Kanaya, Takatsugu Hirokawa, Shogo Nakajima, Koichi Watashi, Tsuyoshi Shirai   +9 more
wiley   +1 more source

Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15‐Lipoxygenase‐1‐Mediated Microglia and Endothelial Cell Ferroptosis

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Background. Ferroptosis is a newly identified form of programmed cell death caused by iron‐dependent lipid peroxidation. Our study was designed to determine the expression patterns and role of 15‐lipoxygenase‐1 (ALOX15) in subarachnoid hemorrhage (SAH) and to investigate whether cepharanthine (CEP) can inhibit ferroptosis by inhibiting ALOX15 in ...
Shiqi Gao, Liuzhi Zhou, Jianan Lu, Yuanjian Fang, Haijian Wu, Weilin Xu, Yuanbo Pan, Junjie Wang, Xiaoyu Wang, Jianmin Zhang, Anwen Shao, Hailiang Tang   +11 more
wiley   +1 more source

Dauricine Protects from LPS-Induced Bone Loss via the ROS/PP2A/NF-κB Axis in Osteoclasts

Antioxidants, 2020
Dauricine (DAC), an isoquinoline alkaloid, exhibits anti-inflammatory activity. We hypothesized that DAC may prevent the inflammatory bone loss induced by lipopolysaccharide (LPS).
Hyun-Jung Park, Malihatosadat Gholam Zadeh, Jae-Hee Suh, Hye-Seon Choi   +3 more
doaj   +1 more source

In silico screening of alkaloids as potential inhibitors of epidermal growth factor receptor

Vietnam Journal of Science, Technology and Engineering, 2023
The epidermal growth factor receptor (EGFR) belongs to the HER/erbB receptor tyrosine kinase (RTK) family, serving as a crucial target for cancer treatment. Anti-EGFR drugs, used as a primary treatment for patients with advanced EGFR gene mutations such
Bui Thanh Tung, Pham Thi Kim Dung, Nguyen Nhu Son, Nguyen Bao Kim, Nguyen Hai Ha, Nguyen Thanh Tra   +5 more
doaj   +1 more source

Utilising Network Pharmacology to Explore Underlying Mechanism of Astragalus membranaceus in Improving Sepsis‐Induced Inflammatory Response by Regulating the Balance of IκBα and NF‐κB in Rats

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Objective. The purpose of the present study was to explore the mechanism of Astragalus membranaceus in the treatment of sepsis. Methods. We searched the active components and targets of Astragalus membranaceus using the TCMSP and BATMAN databases. Then, the GeneCards, MalaCards, and OMIM databases were used to screen out relevant targets of sepsis. The
Haiyang Yu, Qihua Ling, Jingwen Cai, Mengzhi Zhang, Huaiquan Liu, Yunzhi Chen, Luiz Felipe Domingues Passero   +6 more
wiley   +1 more source

Network Pharmacology and Molecular Docking‐Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer’s Disease

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Background. Traditional Chinese herbal medicine draws more attention to explore an effective therapeutic strategy for Alzheimer’s disease (AD). Shenqi Yizhi granule (SQYG), a Chinese herbal recipe, has been applied to ameliorate cognitive impairment in mild‐to‐moderate AD patients. However, the overall molecular mechanism of SQYG in treating AD has not
Linshuang Wang, Xiaoyu Xu, Zikang Wang, Qian Chen, Xiaodie Wei, Jingfan Xue, Zhanjun Zhang, Miao Wang, Yanping Li, Junying Zhang, Dongfeng Wei, Weidong Pan   +11 more
wiley   +1 more source

Separation of Oligosaccharides from Lotus Seeds via Medium-pressure Liquid Chromatography Coupled with ELSD and DAD [PDF]

, 2017
peer-reviewedLotus seeds were identified by the Ministry of Public Health of China as both food and medicine. One general function of lotus seeds is to improve intestinal health.
AD Orozco-Cortes, BA Olsen, C Huang, D Feria-Gervasio, D García-Gómez, E Borch, FLY Fong, G Yen, H Kaplan, H Wang, J Li, J Valette, J Yang, Jh Wang, K Nimptsch, M Björklund, M Björklund, M Fernández, M Lv, MT Machado, O Bañuelos, P Hemström, P Weber, PK Mukherjee, R Tabasco, S Challal, S Gusakova, S Wu, T Ignatova, T Ikegami, TCMV Do, W Oleszek, W Zong, X Lu, X Lu, Y García-Curbelo, Y Zhang, YF Zheng, Z Guo, Z Yang   +39 more
core   +1 more source