Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins. [PDF]
Heliyon, 2023 Backgrounds: Liensinine (Lien), Neferine (Nef), Isoliensinine (Iso) and Tetrandrine (Tet), benzylisoquinoline alkaloids (BIAs), have been shown inhibitory effects on pulmonary fibrosis (PF) through anti-inflammatory, anti-oxidative activities, inhibition
Ren HL, Zhang JH, Xiao JH.
europepmc +2 more sources
Identification of a Natural Small Molecule Dauricine for Glioma Therapy through Targeting p53 and VEGFA Pathways. [PDF]
ACS OmegaDing H, Zhang X, Wu R, Cheng Y, Hu M.
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Simultaneous Quantification of Multiple Analytes in Rat Plasma by UHPLC-MS/MS Following Oral Administration of <i>Gastrodiae Rhizoma</i> Extract for Pharmacokinetic Evaluation. [PDF]
MoleculesGastrodiae Rhizoma (GR) is known to have a medicinal and food-based homology. It is used to treat infantile convulsion, epilepsy, spasm, tetanus, and vertigo.
Chen L +6 more
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Sensitive Quantification of Liensinine Alkaloid Using a HPLC-MS/MS Method and Its Application in Microvolume Rat Plasma. [PDF]
J Anal Methods Chem, 2021 Liensinine, an important alkaloid in lotus seed, exhibits multiple functions such as anti-AIDS, anticancer, antidepressant, and antihypertensive properties.
Wei F, Gou X, Xu X, Wang S, Bao T.
europepmc +2 more sources
Research Progress on Natural Products' Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels. [PDF]
Cardiovasc Ther, 2022 Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients’ medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed.
He J, Li S, Ding Y, Tong Y, Li X.
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Network pharmacology-based mechanism analysis of dauricine on the alleviating Aβ-induced neurotoxicity in Caenorhabditis elegans. [PDF]
BMC Complement Med TherBackground Dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid isolated from the root of Menispermum dauricum DC, exhibits promising anti-Alzheimer’s disease (AD) effects, but its underlying mechanisms remain inadequately investigated.
Zhang R +6 more
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Frontiers in Cell and Developmental Biology, 2021 Alzheimer's disease (AD) is characterized by extracellular amyloid plaques composed of β-amyloid (Aβ) and intracellular neurofibrillary tangles containing hyperphosphorylated tau protein. No effective therapy is available for this disease. In this study,
Chongyang Chen +8 more
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Stylopine: A potential natural metabolite to block vascular endothelial growth factor receptor 2 (VEGFR2) in osteosarcoma therapy. [PDF]
Front Pharmacol, 2023 Vascular endothelial growth factor (VEGF) signals cell survival, cell migration, osteogenesis, cell proliferation, angiogenesis, and vascular permeability by binding to VEGF receptor 2 (VEGFR-2).
Velayutham NK +14 more
europepmc +3 more sources
Synthesis and Evaluation of (Bis)benzyltetrahydroisoquinoline Alkaloids as Antiparasitic Agents. [PDF]
JACS AuVisceral leishmaniasis and Chagas disease are protozoan neglected tropical diseases that have a significant impact in developing countries. Current therapies are limited and suffer from poor safety profiles, creating a dire need for novel drug leads. Bis-
Sozanschi A +6 more
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Advanced Science, Volume 10, Issue 24, August 25, 2023., 2023 The roles of ferroptosis contributing to neurodegenerative diseases and strokes are described, and the emerging data in treating these diseases through pharmacological inhibition of ferroptosis, highlighting a potential promising therapeutic avenue that could be used to prevent neurodegenerative diseases and strokes are summarized.
Yumin Wang +4 more
wiley +1 more source