Results 11 to 20 of about 649 (161)

Corrigendum: Dauricine attenuates vascular endothelial inflammation through inhibiting NF-κB pathway. [PDF]

Front Pharmacol, 2023
Hu J, Chen R, An J, Wang Y, Liang M, Huang K.   +5 more
europepmc   +5 more sources

Comprehensive Analysis of Sinomenii caulis and Menispermi rhizoma Based on Ultra-High Performance Liquid Chromatography and Ultra-High Performance Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry. [PDF]

Anal Sci Adv
ABSTRACT Sinomenii caulis (SC) and Menispermi rhizoma (MR) are Chinese herbal medicines from the same family and are often confused. To achieve identification of SC and MR, the paper used the differential chemical components and the combination characteristics of chemical components to carry out a comprehensive analysis.
Tao Y, Zhang X, Li W, Wu Z, Duan S, Wan L, Li X, Zhang Y, Cheng X, Wei F.   +9 more
europepmc   +3 more sources

Molecular docking study and molecular dynamics simulation of spice metabolites against main protease enzymes and NSP3 macrodomain SARS CoV-2 [PDF]

Pharmaciana, 2022
COVID-19 is still a global pandemic. The transmission is very fast and wide. Its prevalence continues to increase. There is no specific antiviral drug for SARS CoV 2 yet.
Purwaniati, Purwaniati, Roni, Asep
core   +5 more sources

Regulation of Microglia-Activation-Mediated Neuroinflammation to Ameliorate Ischemia-Reperfusion Injury via the STAT5-NF-κB Pathway in Ischemic Stroke. [PDF]

Brain Sci, 2022
Inflammatory reaction after ischemia-reperfusion contributes significantly to a worsened prognosis, and microglia activation is the main resource of inflammation in the nervous system.
Pu Z, Xia S, Shao P, Bao X, Wu D, Xu Y.
europepmc   +2 more sources

Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke. [PDF]

J Inflamm Res, 2022
Zhijun Pu,1– 5 Xinyu Bao,1– 5 Shengnan Xia,1– 5 Pengfei Shao,1– 5 Yun Xu1– 5 1Department of Neurology, Nanjing Drum Tower Hospital, Medical School and the State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, Jiangsu, 210008,
Pu Z, Bao X, Xia S, Shao P, Xu Y.
europepmc   +2 more sources

Dauricine Overcomes Osimertinib Resistance in Lung Cancer by Inducing Ferroptosis via Stabilizing SAT1. [PDF]

Cancer Sci
Our study explores the potential of dauricine, a bioactive compound from Menispermum dauricum, to overcome osimertinib resistance in lung cancer. We demonstrate that dauricine, when combined with osimertinib, induces ferroptosis in resistant lung cancer cells by stabilizing SAT1, a key enzyme in oxidative stress regulation.
Men B, Chen Z, Ge H, Yang Z, Yun L, Jiang J, Dian M, He Y, Zhou Z, Zhang R, Yan T, Li Z, Zhang Y, He Y, He J, Rao X, Rao S.   +16 more
europepmc   +2 more sources

Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer. [PDF]

Food Sci Nutr
DAU inhibits macrophage M2 polarization and promotes ferroptosis through HCK. DAU mediates TAMs M2 polarization to inhibit the proliferation, migration, invasion, and in vivo metastasis and reverses the reduction of ferroptosis via the IDO1 pathway in BLCA.
Gong J, Sun D, Zheng Y, Mao C, Yu B, Li X, Xuan Y.   +6 more
europepmc   +2 more sources

The Tacrine-Induced Endoplasmic Reticulum Stress in AChE-Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose. [PDF]

J Neurochem
Acetylcholinesterase (AChE) inhibitors are a class of drugs to treat Alzheimer's disease (AD). Our study reveals that some AChE inhibitors, for example, tacrine, disrupt the proper assembly and transport of oligomeric forms of AChE, resulting in endoplasmic reticulum (ER) stress. The ER stress ultimately leads to cell apoptosis. This tacrine‐induced ER
Wang X, Xia Y, Guo MS, Wu J, Dilidaer A, Gao J, Dong TT, Zhu Y, Tsim KWK.   +8 more
europepmc   +2 more sources

Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease. [PDF]

Drug Deliv, 2021
Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive and memory-related impairment.
Wang K, Wang L, Chen L, Peng C, Luo B, Mo J, Chen W.   +6 more
europepmc   +2 more sources

Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson's disease treatment through network pharmacology and transcriptomics. [PDF]

Sci Rep
Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, poses significant challenges to single-target therapeutic strategies due to its complex etiology.
Xu QH, Wang YL, Wang C, Jiang SS, Zhang BR, Tian J.   +5 more
europepmc   +2 more sources