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Dauricine: Review of Pharmacological Activity [PDF]
Drug Design, Development and TherapyDauricine is an important natural organic compound in Menispermum dauricum, which often has significant biological activity.The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of dauricine in recent years.Web of Science (121 articles) and PubMed databases (97 articles) were used to ...
Chen KQ, Wang SZ, Lei HB, Liu X.
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Dauricine Attenuates Vascular Endothelial Inflammation Through Inhibiting NF-κB Pathway [PDF]
Frontiers in Pharmacology, 2021 Endothelial cells are the fundamental components of blood vessels that regulate several physiological processes including immune responses, angiogenesis, and vascular tone. Endothelial dysfunction contributes to the development of various diseases such as acute lung injury, and endothelial inflammation is a vital part of endothelial dysfunction ...
Ji Hu, Ru Chen, Yilong Wang
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Herbal Compounds Dauricine and Isoliensinine Impede SARS-CoV-2 Viral Entry. [PDF]
Biomedicines, 2023 Targeting viral entry has been the focal point for the last 3 years due to the continued threat posed by SARS-CoV-2. SARS-CoV-2’s entry is highly dependent on the interaction between the virus’s Spike protein and host receptors. The virus’s Spike protein is a key modulator of viral entry, allowing sequential cleavage of ACE2 at the S1/S2 and S2 sites ...
Dabrell SN +4 more
europepmc +5 more sources
Dauricine Impedes the Tumorigenesis of Lung Adenocarcinoma by Regulating Nrf2 and Reactive Oxygen Species. [PDF]
CellsDauricine has been shown to possess intriguing anti-cancerous activities against various malignancies. The current study examined the inhibitory effects of dauricine against lung adenocarcinoma with cell lines and animal models. MTT assay was performed in three different lung adenocarcinoma cell lines using a concentration range of dauricine.
Yousuf W +13 more
europepmc +5 more sources
Dauricine can inhibit the activity of proliferation of urinary tract tumor cells
Asian Pacific Journal of Tropical Medicine, 2012 To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain, prostate cancer PC-3Mcell strain and primary cell culture system.The main effective component-phenolic alkaloids ofMenispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical method.
Wang, Jun +4 more
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Novel dauricine derivatives suppress cancer via autophagy-dependent cell death
Bioorganic Chemistry, 2019 Eleven dauricine derivatives were synthesized and evaluated for their anti-cancer effect in different cancer cells and their autophagic activity in HeLa model cell. Among these newly synthesized compounds, carbamates 2a, 2b, carbonyl ester 3a and sulfonyl ester 4a exhibited potent cytotoxic effects on tested cancer cells with IC50 values ranged from 2 ...
Xiaobo Zhou, Yuan Qing Qu, Zhiyuan Zheng
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Determination and pharmacokinetic study of dauricine in rat plasma by UPLC–MS/MS [PDF]
Acta Chromatographica, 2018 Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C., a bisbenzylisoquinoline alkaloid derivative, and has shown multiple pharmacological properties. In this work, a sensitive and selective ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed for determination of ...
Peiwu Geng +5 more
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Oncology Letters, 2019 Pancreatic cancer is a highly malignant cancer associated with high expression levels of sonic hedgehog signaling molecule (Shh), patched 1 (Ptch1), smoothened frizzled class receptor (Smo) and glioma-associated oncogene family zinc finger 1 (Gli1) in the hedgehog (Hh) signaling pathway. Inhibition of the Hh signaling pathway is a potential therapeutic
Zhang, Ying-Bo +5 more
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P-glycoprotein inhibition increases the transport of dauricine across the blood-brain barrier
Molecular Medicine Reports, 2013 Dauricine is the major bioactive component isolated from the roots of Menispermum dauricum D.C. The aim of the present study was to investigate the role of P‑glycoprotein in the transport of dauricine across the blood‑brain barrier by pre‑treatment with the P‑glycoprotein inhibitor verapamil.
Pei-Liang, Dong +5 more
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Synthesis of an analog of the alkaloid dauricine [PDF]
Chemistry of Natural Compounds, 1977 G. N. Dorofeenko, E. I. Sadekova
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