Results 31 to 40 of about 753,963 (247)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
AVALIAÇÃO DO PERFIL CINÉTICO DOS PARÂMETROS PLAQUETÁRIOS EM PACIENTES COM SEPSE
Hematology, Transfusion and Cell TherapyIntrodução: A sepse é definida como uma síndrome clínica causada por uma resposta desregulada do hospedeiro frente a uma infecção, podendo levar à disfunção de múltiplos órgãos e óbito.
CA Sepanski, DC Kalva
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Treatment of sleep-disordered breathing with positive airway pressure devices: technology update
Medical Devices: Evidence and Research, 2015 Karin Gardner Johnson, Douglas Clark Johnson Department of Medicine, Baystate Medical Center, Springfield, MA, USA Abstract: Many types of positive airway pressure (PAP) devices are used to treat sleep-disordered breathing including obstructive sleep ...
Johnson KG, Johnson DC
doaj
5 Reasons Why Scoliosis X-Rays Are Not Harmful
Dose-Response, 2020 Radiographic imaging for scoliosis screening, diagnosis, treatment, and management is the gold standard assessment tool. Scoliosis patients receive many repeat radiographs, typically 10-25 and as many as 40-50, equating to a maximum 50 mGy of cumulative ...
Paul A. Oakley DC, MSc +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Agro-ecological zones : The development of a regional classification scheme for Rwanda [PDF]
Tropicultura, 1987 This paper discusses the need for a regional classification scheme that enables agricultural planners and researchers in Rwanda to take account of the country's major variations in agro-ecological conditions.
Clay, DC., Dejaegher, YMJ.
doaj
Improving Adherence to Topical Medication in Patients with Glaucoma
Patient Preference and Adherence, 2021 Ian Tapply,1,2 David C Broadway1,3 1Department of Ophthalmology, Norfolk and Norwich University Hospital, Norwich, NR4 7UY, UK; 2Department of Ophthalmology, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK; 3School of Pharmacy, University of East Anglia ...
Tapply I, Broadway DC
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source