Results 51 to 60 of about 860,720 (284)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Modular multi-level DC-DC converter for high-power and high-voltage applications [PDF]
, 2015 A transformer-less DC-DC Modular Multi-level Converter (DC-DC-MMC) topology based on H-bridge cells is proposed in this paper. The suggested DC-DC-MMC can be used to either control the power flow in a HVdc grid or interconnect HVdc lines with ...
Belenguer Balaguer, Enrique +4 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Plug and Play DC-DC Converters for Smart DC Nanogrids with Advanced Control Ancillary Services [PDF]
, 2018 This paper gives a general view of the control possibilities for dc-dc converters in dc nanogrids. A widely adopted control method is the droop control, which is able to achieve proportional load sharing among multiple sources and to stabilize the ...
Caldognetto, Tommaso +4 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Orthopaedic Journal of Sports MedicineObjectives To evaluate the association between medial meniscus posterior root tear (MMRT) with anthropometric characteristics of the patient (age, weight, and height) and associated injuries identified on MRI (meniscal extrusion, medial collateral ...
DC Astur, M Cohen
doaj +1 more source
5 Reasons Why Scoliosis X-Rays Are Not Harmful
Dose-Response, 2020 Radiographic imaging for scoliosis screening, diagnosis, treatment, and management is the gold standard assessment tool. Scoliosis patients receive many repeat radiographs, typically 10-25 and as many as 40-50, equating to a maximum 50 mGy of cumulative ...
Paul A. Oakley DC, MSc +2 more
doaj +1 more source
Design zero-voltage switching DC-DC buck converter [PDF]
, 2014 This report proposes an integrated, high switching frequency, zero-voltage-switching dc-dc buck converter for battery charger application. The design and analysis of dc dc buck converter with integrated inductor is presented.
Chan, S. W. +4 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source