Results 61 to 70 of about 860,720 (284)

Cancer Mortality for a Single Race in Low Versus High Elevation Counties in the U.S.

open access: yesDose-Response, 2011
A previous study compared cancer mortality in the six lowest versus six highest elevations in the U.S. for all races. This study looks at a single race since death rates tend to vary by race. In this ecological study, cancer mortality rates were compared
John Hart DC, MHSc
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Update on rescue therapies in patients with lamivudine-resistant chronic hepatitis B

open access: yesDrug Design, Development and Therapy, 2013
Daniel C Chao, Ke-Qin HuDivision of Gastroenterology and Hepatology, University of California, Irvine Medical Center, Orange, CA, USAAbstract: Chronic hepatitis B continues to be a global problem, with an estimated 240 million cases according to the
Chao DC, Hu KQ
doaj  

ICTERÍCIA NEONATAL: QUANDO DEVEMOS PENSAR EM ESFEROCITOSE?

open access: yesHematology, Transfusion and Cell Therapy
Introdução: A estrutura da membrana eritrocitária é dividida em interações verticais, que são responsáveis pela estabilidade da bicamada de lipídeos, e interações horizontais que conferem a integridade das estruturas da membrana. Na esferocitose há lesão
LG Oliveira, DC Barros
doaj   +1 more source

Association of Hypertension Mortality Rates with Geographic Concentrations of Chiropractors and Medical Doctors in the U.S., 2008

open access: yesDose-Response, 2013
As concentration (dose) of health care providers increases, health outcomes (responses) are expected to be favorable (e.g., decrease in mortality rates). Accordingly, this data-driven, ecological study compares hypertension mortality rates in the U.S. by
John Hart DC, MHSc
doaj   +1 more source

Global noise studies for CMS Tracker upgrade [PDF]

open access: yes, 1999
7 páginas, 6 figuras.-- Trabajo presentado al "Topical Workshop on Electronics for Particle Physics 2010 (TWEPP-10)" celebrado en Alemania.-- Open Access.-- et al.The characterization of the noise emissions of DC-DC converters at system level is critical
F Arteche   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Reproducing single-carrier digital modulation schemes for VLC by controlling the first switching harmonic of the dc-dc power converter output voltage ripple [PDF]

open access: yes, 2018
A DC-DC power converter based on a two-phase synchronous buck converter that reproduces single-carrier digital modulation schemes by controlling the first switching harmonic of the output voltage ripple is presented in this work.
Fernández Miaja, Pablo   +3 more
core   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

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