Results 91 to 100 of about 455,909 (199)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Glymphatic-DCE-MRI pre-processing code

, 2021
This project contains the code for processing the DCE-MRI data to derive the psnrv imagery.
Hedok Lee
core   +1 more source

Comparative Study Between Digital Tomosynthisis and Dynamic Contrast Enhanced MRI in Diagnosis of Malignant Breast Cancer [PDF]

Al-Azhar International Medical Journal
Background: All throughout the globe, people are dealing with the devastating effects of breast cancer (BC). It ranks first among female cancers in both industrialized and underdeveloped nations. Aim of the study: To assess the efficacy of DCT and SPECT/
Noha Elsaid, Aisha Mohamed, Manal Khaled, Sara Mohammad   +3 more
doaj   +1 more source

Disentangling the effect of brain insulin resistance on brain health (BIR‐BrainHealth): Rationale and study protocol

Diabetic Medicine, EarlyView.
Abstract Aims Insulin signalling in the brain is crucial for systemic metabolic regulation and cognitive function. In some individuals, these effects are reduced, a phenomenon referred to as brain insulin resistance (BIR). This condition may contribute to the elevated risk of cognitive decline and dementia in diabetes, yet its prevalence, mechanisms ...
Sabrina Wangler, Peter Sørensen, Konni Kass, Nicole Jaqueline Jensen, Mark Bitsch Vestergaard, Julia Hummel, Ronja Völk, Julie Christine Antvorskov, Flemming Pociot, Jørgen Rungby, Martin Heni, Henrik Bo Wiberg Larsson   +11 more
wiley   +1 more source

Molecular subtypes classification of breast cancer in DCE-MRI using deep features

Breast cancer is a major cause of concern on a global scale due to its high incidence rate. It is one of the leading causes of death for women, if left untreated.
Hasan, A.M., Al-Waely, N.K.N., Jalab, H.A., Noor K.N. Al-Waely, Hadeel K. Aljobouri, Ali M. Hasan, Aljobouri, H.K., Ibrahim, R.W., Meziane, F., Rabha W. Ibrahim, Farid Meziane, Hamid A. Jalab   +11 more
core   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Cross‐Modal Artificial Intelligence Integrating Dynamic MRI and Clinical Data for Breast Cancer Diagnosis and Nodal Metastasis Prediction

MedComm – Oncology, Volume 5, Issue 4, December 2026.
A multicenter artificial intelligence framework was developed and externally validated for breast lesion classification and axillary lymph node metastasis prediction. Using dynamic contrast‐enhanced MRI alone for lesion classification and integrating MRI with preoperative clinical and biopsy‐derived information for nodal prediction, the framework ...
Wei Ren, Zifan He, Zhixian Deng, Zhenjun Huang, Gengxi Cai, Xiaohua Ban, Qiugen Hu, Zebang Zhang, Luhui Mao, Yujie Tan, Qing Peng, Zehua Wang, Ruichong Lin, Xian Yang, Xiaohui Duan, Herui Yao, Yunfang Yu   +16 more
wiley   +1 more source

DCE-MRI perfusion and permeability parameters as predictors of tumor response to CCRT in patients with locally advanced NSCLC

, 2016
In this prospective study, 36 patients with stage III non-small cell lung cancers (NSCLC), who underwent dynamic contrast-enhanced MRI (DCE-MRI) before concurrent chemo-radiotherapy (CCRT) were enrolled. Pharmacokinetic analysis was carried out after non-
Tryphon Lambrou (17161762), Xiao Xu (112147), Yu Tang (343157), Yu Men (9203783), Ning Wu (132667), Lvhua Wang (2837315), Li Liu (75607), Zihua Su (709962), Han Ouyang (709961), Feng Ye (173489), Xiuli Tao (9508928), Zhouguang Hui (3406451), Ying Song (352782)   +12 more
core   +2 more sources

Reproducibility and comparison of DCE-MRI and DCE-CT perfusion parameters in a rat tumor model

, 2012
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and computed tomography (DCE-CT) provide independent measures of biomarkers related to tumor perfusion.
Ravoori, Murali, Johnson, Valen E., Waterton, John C., Jackson, Edward F., Ng, Chaan S., Brammer, David, Wei, Wei, Kundra, Vikas, Han, Lin, Klumpp, Sherry   +9 more
core   +1 more source