Results 11 to 20 of about 28,831 (253)

Is palpable DCIS more aggressive than screen-detected DCIS?

Surgery Open Science, 2023
Palpable ductal carcinoma in-situ (pDCIS) is a subset of DCIS presenting with a clinical mass. We hypothesized pDCIS would have more aggressive clinical and pathological features, and higher rates of recurrence and upgrade to invasive disease compared to screen-detected DCIS.We performed a retrospective analysis of female patients (age 28-76) with DCIS
Nina Balac, Robert M. Tungate, Young Ju Jeong, Heather MacDonald, Lily Tung, Naomi R. Schechter, Linda Larsen, Stephen F. Sener, Julie E. Lang, Kirstyn E. Brownson   +9 more
openaire   +4 more sources

DCIS knowledge of women choosing between active surveillance and surgery for low-risk DCIS [PDF]

Breast
Background: Ductal carcinoma in situ (DCIS) can progress to invasive breast cancer (IBC), but often never will. As we cannot predict accurately which DCIS-lesions will or will not progress to IBC, almost all women with DCIS undergo breast-conserving ...
E.G. Engelhardt, R.S.J.M. Schmitz, M.A. Gerritsma, C.M.T. Sondermeijer, E. Verschuur, J.H.E. Houtzager, R. Griffioen, N. Bijker, R.M. Mann, V. Retèl, F.H. van Duijnhoven, J. Wesseling, E.M.A. Bleiker, Alastair Thompson, Serena Nik-Zainal, Elinor J. Sawyer, Helen Davies, Andrew Futreal, Nicholas Navin, E. Shelley Hwang, Jos Jonkers, Jacco van Rheenen, Fariba Behbod, Esther H. Lips, Marjanka Schmidt, Lodewyk F.A. Wessels, Daniel Rea, Proteeti Bhattacharjee, Hilary Stobart, Deborah Collyar, Donna Pinto, Marja van Oirsouw, S. Alaeikhanehshir, L. Elshof   +33 more
doaj   +7 more sources

Integrated Multi-Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC. [PDF]

Adv Sci (Weinh)
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Zhang N, Wan T, Zhang S, Jiang Y, Su P, Liu J, Chen Z, Hao J, Wang H, Chen B, Zhao W, Wang L, Xing T, Zhang Q, Schmitz U, Ding Z, Crosetto N, Liu B, Yang Q.   +18 more
europepmc   +2 more sources

Relationship between altered myoepithelial phenotype and the inflammatory cell infiltrate in progression of DCIS [PDF]

, 2015
The copyright of this thesis rests with the author and no quotation from it or information derived from it may be published without the prior written consent of the authorChanges in the microenvironment have been implicated in the transition of pre ...
Ahmed, Khairiya O
core   +4 more sources

Development of a Nomogram-Based Clinical Estimation Model for Pathological Upstaging in Patients With Preoperative Ductal Carcinoma In Situ. [PDF]

Kaohsiung J Med Sci
ABSTRACT Preoperative diagnosis of ductal carcinoma in situ (DCIS) may be followed by pathological upstaging to invasive ductal carcinoma (IDC) upon surgical excision, a discrepancy that significantly impacts surgical planning and decisions regarding sentinel lymph node biopsy (SLNB).
Chen YH, Li CL, Yang PF, Hsiao HH, Chen FM, Moi SH.   +5 more
europepmc   +2 more sources

The clinical significance of oestrogen receptor expression in breast ductal carcinoma in situ [PDF]

, 2020
Background: Oestrogen receptor (ER) in invasive breast cancer (BC) predicts response to endocrine therapy (ET) and provides prognostic value. In this study, we investigated the value of ER expression in ductal carcinoma in situ (DCIS) in terms of outcome
Macmillan, R. Douglas, Green, Andrew R., Syed, Binafsha M, Oni, Georgette, Khout, Hazem, Tan, Quing, Toss, Michael S, Shiino, Sho, Robertson, John F. R., Rakha, Emad A, Miligy, Islam M   +10 more
core   +1 more source

The dilemma of DCIS

The Breast, 2007
The increasingly frequent diagnosis of ductal carcinoma in situ (DCIS) presents a major clinical dilemma. Our inability to predict which DCIS will progress to invasive cancer or the time interval in which recurrent DCIS or invasive cancer will occur has resulted in treatments ranging from mastectomy to excision and observation being offered to patients.
Monica, Morrow, Martin J, O'Sullivan
openaire   +2 more sources

Modeling the natural history of ductal carcinoma in situ based on population data

Breast Cancer Research, 2020
Background The incidence of ductal carcinoma in situ (DCIS) has increased substantially since the introduction of mammography screening. Nevertheless, little is known about the natural history of preclinical DCIS in the absence of biopsy or complete ...
Sarocha Chootipongchaivat, Nicolien T. van Ravesteyn, Xiaoxue Li, Hui Huang, Harald Weedon-Fekjær, Marc D. Ryser, Donald L. Weaver, Elizabeth S. Burnside, Brandy M. Heckman-Stoddard, Harry J. de Koning, Sandra J. Lee   +10 more
doaj   +1 more source

Unmasking the immune microecology of ductal carcinoma in situ with deep learning

npj Breast Cancer, 2021
Despite increasing evidence supporting the clinical relevance of tumour infiltrating lymphocytes (TILs) in invasive breast cancer, TIL spatial variability within ductal carcinoma in situ (DCIS) samples and its association with progression are not well ...
Priya Lakshmi Narayanan, Shan E. Ahmed Raza, Allison H. Hall, Jeffrey R. Marks, Lorraine King, Robert B. West, Lucia Hernandez, Naomi Guppy, Mitch Dowsett, Barry Gusterson, Carlo Maley, E. Shelley Hwang, Yinyin Yuan   +12 more
doaj   +1 more source

Ductal Carcinoma In Situ (DCIS) and Microinvasive DCIS: Role of Surgery in Early Diagnosis of Breast Cancer [PDF]

, 2023
Advances in treatments, screening, and awareness have led to continually decreasing breast cancer-related mortality rates in the past decades. This achievement is coupled with early breast cancer diagnosis.
Veronesi P., Abruzzese G., Galimberti V., Bianchi B., Sacchini V., Corso G., Magnoni F., Di Silvestre S., Alloggio E. A.   +8 more
core   +2 more sources