Results 21 to 30 of about 28,831 (253)

Essential role of STAT5a in DCIS formation and invasion following estrogen treatment [PDF]

, 2020
Ductal carcinoma in situ (DCIS) is one of the earliest stages of breast cancer (BCa). The mechanisms by which DCIS lesions progress to an invasive state while others remain indolent are yet to be fully characterized and both diagnosis and treatment of ...
Dees, S, Jasmin, J-F, Sotgia, F, Pontiggia, L, Mercier, I, Lisanti, MP   +5 more
core   +1 more source

Immune microenvironment in ductal carcinoma in situ: a comparison with invasive carcinoma of the breast

Breast Cancer Research, 2020
Background The immune microenvironment in ductal carcinoma in situ (DCIS) and its significance are not well established. This study was conducted to evaluate the immune microenvironment of DCIS including the composition of tumor-infiltrating lymphocyte ...
Milim Kim, Yul Ri Chung, Hyun Jeong Kim, Ji Won Woo, Soomin Ahn, So Yeon Park   +5 more
doaj   +1 more source

Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ [PDF]

, 2019
© 2018, United States & Canadian Academy of Pathology. Legumain is a proteolytic enzyme that plays a role in the regulation of cell proliferation in invasive breast cancer.
Miligy, Islam M., Rakha, Emad A., Alkawaz, Abdulbaqi, Green, Andrew R., Toss, Michael S., McCaffrey, L., Ellis, Ian O., Abidi, Asima, Gorringe, Kylie L.   +8 more
core   +1 more source

The prognostic significance of lysosomal protective protein (Cathepsin A) in breast ductal carcinoma in situ [PDF]

, 2019
Background: Cathepsin A (CTSA) is a key regulatory enzyme for galactoside metabolism. Additionally, it has a distinct proteolytic activity and plays a role in tumour progression. CTSA is differentially expressed at the mRNA level between breast
Haj-Ahmad, Rita, AlKawaz, A, Rita Haj‐Ahmad, Toss, MS, Kylie L Gorringe, Ian O Ellis, Toss, Michael S., Abdulbaqi AlKawaz, AlKawaz, Abdulbaqi, Mittal, Karuna, Miligy, Islam M., Green, Andrew R., Michael S Toss, Miligy, IM, Emad A Rakha, Islam M Miligy, Green, AR, Rakha, EA, Karuna Mittal, Gorringe, KL, Mittal, K, Ellis, IO, Rakha, Emad A., Haj-Ahmad, R, Ellis, Ian O., Andrew R Green, Gorringe, Kylie L.   +26 more
core   +1 more source

Different distribution of breast ductal carcinoma in situ, ductal carcinoma in situ with microinvasion, and invasion breast cancer

World Journal of Surgical Oncology, 2012
Background Breast ductal cancer in situ (DCIS) can recur or progress to invasive ductal cancer (IDC), and the interim stage include DCIS with microinvasion (DCIS-Mi).
Wei Zhang, Er-li Gao, Yi-li Zhou, Qi Zhai, Zhang-yong Zou, Gui-long Guo, Guo-rong Chen, Hua-min Zheng, Guan-li Huang, Xiao-hua Zhang   +9 more
doaj   +1 more source

Geometric characteristics of collagen have independent prognostic significance in breast ductal carcinoma in situ: an image analysis study [PDF]

, 2019
Collagen plays a key role in normal and malignant tissue homeostasis. While the prognostic significance of collagen fibre remodeling in invasive breast cancer has been studied, its role in ductal carcinoma in situ (DCIS) remains poorly defined.
Alkawaz, Abdulbaqi, Ellis, Ian O, Roxanis, Ioannis, Gorringe, Kylie L, Green, Andrew R, Toss, Michael S, Aneja, Ritu, Rakha, Emad A, Miligy, Islam M, Mittal, Karuna   +9 more
core   +1 more source

Molecular subtyping of DCIS : heterogeneity of breast cancer reflected in pre-invasive disease [PDF]

, 2010
Background: Molecular profiling has identified at least four subtypes of invasive breast carcinoma, which exhibit distinct clinical behaviour. There is good evidence now that DCIS represents the non-obligate precursor to invasive breast cancer and ...
Jones, J. Louise, J L Jones, Jane Warwick, S E Clark, Warwick, Jane, R L Bowen, Clark, S. E., S W Duffy, Duffy, Stephen W., Bowen, Rebecca, Carpenter, R., J Warwick, R Carpenter   +12 more
core   +1 more source

Molecular signatures of in situ to invasive progression for basal-like breast cancers: An integrated mouse model and human DCIS study

npj Breast Cancer, 2022
Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of Invasive Ductal Carcinoma (IDC) and thus the identification of features that may predict DCIS progression would be of potential clinical value.
Aatish Thennavan, Susana Garcia-Recio, Siyao Liu, Xiaping He, Charles M. Perou   +4 more
doaj   +1 more source

Does Existence of Ductal Carcinoma In Situ Accompanying Invasive Ductal Carcinoma Lead to Different Clinicopathological Features and Clinical Outcome? Report of a Breast Cancer Registry [PDF]

Middle East Journal of Cancer, 2022
Background: Ductal carcinoma in situ (DCIS) is widely recognized as the precursor of invasive ductal carcinoma (IDC). We aimed to compare clinicopathological characteristics and prognosis between IDC with and without coexisting DCIS stratified by ...
Sedigheh Tahmasebi, Baharak Shahin, Masoumeh Ghoddusi Johari, Majid Akrami, Vahid Zanguri, Abdolrasoul Talei, Zahra Keumarsi, Nazanin Karimaghaei   +7 more
doaj   +1 more source

Learning protein binding affinity using privileged information

BMC Bioinformatics, 2018
Background Determining protein-protein interactions and their binding affinity are important in understanding cellular biological processes, discovery and design of novel therapeutics, protein engineering, and mutagenesis studies.
Wajid Arshad Abbasi, Amina Asif, Asa Ben-Hur, Fayyaz ul Amir Afsar Minhas   +3 more
doaj   +1 more source