Results 41 to 50 of about 28,831 (253)

The natural history of ductal carcinoma in situ (DCIS) in simulation models: A systematic review

Breast, 2023
Objective: Assumptions on the natural history of ductal carcinoma in situ (DCIS) are necessary to accurately model it and estimate overdiagnosis. To improve current estimates of overdiagnosis (0–91%), the purpose of this review was to identify and ...
Keris Poelhekken, Yixuan Lin, Marcel J.W. Greuter, Bert van der Vegt, Monique Dorrius, Geertruida H. de Bock   +5 more
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Identification of biomarkers in ductal carcinoma in situ of the breast with microinvasion

BMC Cancer, 2008
Background Widespread use of mammography in breast cancer screening has led to the identification of increasing numbers of patients with ductal carcinoma in situ (DCIS).
Iyama Ken-ichi, Honda Yumi, Ibusuki Mutsuko, Kawasoe Teru, Toyama Tatsuya, Zhang Zhenhuan, Yamamoto Yutaka, Okumura Yasuhiro, Yamashita Hiroko, Iwase Hirotaka   +9 more
doaj   +1 more source

A Survey of the Recent Trends in Deep Learning Based Malware Detection

Journal of Cybersecurity and Privacy, 2022
Monitoring Indicators of Compromise (IOC) leads to malware detection for identifying malicious activity. Malicious activities potentially lead to a system breach or data compromise.
Umm-e-Hani Tayyab, Faiza Babar Khan, Muhammad Hanif Durad, Asifullah Khan, Yeon Soo Lee   +4 more
doaj   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Design and Performance Analysis of an Anti-Malware System Based on Generative Adversarial Network Framework

IEEE Access
The cyber realm is overwhelmed with dynamic malware that promptly penetrates all defense mechanisms, operates unapprehended to the user, and covertly causes damage to sensitive data.
Faiza Babar Khan, Muhammad Hanif Durad, Asifullah Khan, Farrukh Aslam Khan, Muhammad Rizwan, Aftab Ali   +5 more
doaj   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Modern visualization diagnostic methods of non-invasive breast carcinomas (review of literature)

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Relevance. Breast carcinomas (BC) remain one of the most actual problems of modern oncology. According to statistics, the incidence of BC is steadily increasing, making it the most common cancer pathology among women.
D. A. Maksimov, A. M. Morozov, E. V. Penyaz', V. V. Rogovenko, M. A. Belyak   +4 more
doaj   +1 more source

Evaluation of BRCAPRO risk assessment model in patients with ductal carcinoma in situ who underwent clinical BRCA genetic testing.

Frontiers in Genetics, 2016
The authors retrospectively aimed to determine which of the following 3 scenarios, related to DCIS entry into BRCAPRO, predicted BRCA mutation status more accurately: 1) DCIS as an invasive breast cancer (IBC) entered using the actual age of diagnosis, 2)
Nisreen eElsayegh, Angelica M. Gutierrez Barrera, Kimberly I. Muse, Heather eLin, Henry M Kuerer, Monica eHelm, Jennifer K. Litton, Banu K. Arun, Banu K. Arun   +8 more
doaj   +1 more source