Results 51 to 60 of about 29,583 (248)

Tracking CDK1 Dynamics With a Novel Biosensor Mouse and Clinical Cohorts to Predict CDK4/6 Inhibitor Sensitivity in ER+ Breast Cancer

Advanced Science, EarlyView.
Cyclin‐dependent kinase (CDK) 1 activity is a dynamic marker of treatment response in estrogen receptor positive breast cancer. Patient cohorts reveal CDK1 activity increases during progression to invasive disease, where high expression correlates with poor survival. Using a novel Cdk1 biosensor mouse alongside in vitro models, we demonstrate that CDK1
Sarah Alexandrou, Kristine J. Fernandez, Min Li Huang, Ewan K. A. Millar, Claire Vennin, Leila Eshraghi, Tan Dat Timothy Lam, Victoria Lee, Nyah C. Brooks, Janett Stoehr, Cristian Guaman Mendez, Douglas Strathdee, David Stevenson, David Herrmann, Sandra O'Toole, Paul Timpson, Max Nobis, C. Elizabeth Caldon   +17 more
wiley   +1 more source

Design and Performance Analysis of an Anti-Malware System Based on Generative Adversarial Network Framework

IEEE Access
The cyber realm is overwhelmed with dynamic malware that promptly penetrates all defense mechanisms, operates unapprehended to the user, and covertly causes damage to sensitive data.
Faiza Babar Khan, Muhammad Hanif Durad, Asifullah Khan, Farrukh Aslam Khan, Muhammad Rizwan, Aftab Ali   +5 more
doaj   +1 more source

Remote Ischemic Post‐Conditioning Preserves the Neurovascular Unit by Brain‐Derived Gas6 That Drives Monocyte‐Derived Macrophage Reprogramming via Axl and Vimentin after SAH

Advanced Science, EarlyView.
Subarachnoid hemorrhage (SAH) triggers monocyte‐derived macrophage (MDM) infiltration and M1‐like polarization via Vimentin upregulation, leading to neurovascular unit disruption and cognitive dysfunction. Remote ischemic postconditioning (RIPostC) upregulates neuronal Gas6, which activates Axl on MDMs to downregulate Vimentin and drive reparative M2 ...
Yajun Zhu, Zichao Huang, Xi Rong, Xingwei Lei, Fuming Liang, Xiaoguo Li, Jiru Zhou, Yu Wang, Yifan Huang, Shuang Tang, Jianjun Zhong, Jin Yan, Hongji Deng, Chun Zeng, Zongduo Guo   +14 more
wiley   +1 more source

Boost und Hypofraktionierung beim DCIS

InFo Hämatologie + Onkologie, 2022
Zwischen Juni 2007 und Juni 2014 wurden 1608 Patientinnen in die Studie aufgenommen. Von den Patientinnen wurden 503 bezüglich Boost und Fraktionierung randomisiert, 581 wurden randomisiert für den Boost bei Vorauswahl für konventionelle Fraktionierung und 524 randomisiert bei Vorauswahl für Hypofraktionierung.
Dunst, Jürgen, Krug, David
openaire   +3 more sources

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Evaluation of BRCAPRO risk assessment model in patients with ductal carcinoma in situ who underwent clinical BRCA genetic testing.

Frontiers in Genetics, 2016
The authors retrospectively aimed to determine which of the following 3 scenarios, related to DCIS entry into BRCAPRO, predicted BRCA mutation status more accurately: 1) DCIS as an invasive breast cancer (IBC) entered using the actual age of diagnosis, 2)
Nisreen eElsayegh, Angelica M. Gutierrez Barrera, Kimberly I. Muse, Heather eLin, Henry M Kuerer, Monica eHelm, Jennifer K. Litton, Banu K. Arun, Banu K. Arun   +8 more
doaj   +1 more source

ALDH5A1 is over-expressed in DCIS models.

, 2012
Whole cell lysates from 3D rBM overlay cultures of MCF10A, MCF10.DCIS, SUM102 and SUM225 were probed for ALDH5A1 (upper panel) and for GAPDH (lower panel) as a loading control.
Stephen A. Krawetz (113433), Mansoureh Sameni (113429), Quanwen Li (113426), Bonnie F. Sloane (113436), Raymond R. Mattingly (113438), Shihong Mao (113422), Hitchintan Kaur (113418)   +6 more
core   +1 more source

SpaCut: Transcript‐Aware Morphology Fusion for Robust Cell Segmentation in Subcellular Spatial Transcriptomics

Advanced Science, EarlyView.
Subcellular spatial transcriptomics enables high‐resolution mapping of gene expression within tissues, but accurate cell segmentation is essential for assigning transcripts to individual cells. We present SpaCut, a deep learning framework that integrates transcriptomic features with nucleus‐guided morphological information to precisely delineate cell ...
Yongheng Li, Fangfang Zhu, Wenwen Min
wiley   +1 more source

Neuro-evolutionary computing approach for an epidemic model of ransomware detection using morlet wavelet neural network with meta-heuristic optimization

Scientific Reports
This paper presents an algorithmic paradigm that will address a malware model in the form of a nonlinear set of differential equations. The neural networks are Morlet wavelet as estimate the state variables of the malware behavior.
Zain Ul Abideen Khan, Muhammad Abid Mughal, Irfan Ul Haq, Muhammad Naeem Aslam, Bouthaina Dammak, Abdullatif Ghallab   +5 more
doaj   +1 more source

Modern visualization diagnostic methods of non-invasive breast carcinomas (review of literature)

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье
Relevance. Breast carcinomas (BC) remain one of the most actual problems of modern oncology. According to statistics, the incidence of BC is steadily increasing, making it the most common cancer pathology among women.
D. A. Maksimov, A. M. Morozov, E. V. Penyaz', V. V. Rogovenko, M. A. Belyak   +4 more
doaj   +1 more source