Results 71 to 80 of about 47,798 (276)

Age at First Pregnancy, Adult Weight Gain and Postmenopausal Breast Cancer Risk: The PROCAS Study (United Kingdom)

International Journal of Cancer, EarlyView.
An early first pregnancy is protective against postmenopausal breast cancer. However, pregnancy is also a key contributor to weight gain, and adult weight gain increases postmenopausal breast cancer risk. This prospective cohort study quantified the combined effect of adult weight gain and age at first pregnancy on postmenopausal breast cancer risk ...
Lee Malcomson, Adam Brentnall, Andrew G. Renehan, Mary Pegington, Elaine F. Harkness, Jake Southworth, D. Gareth Evans, Michelle Harvie   +7 more
wiley   +1 more source

Overall survival is improved when DCIS accompanies invasive breast cancer

Scientific Reports, 2019
Invasive ductal carcinoma (IDC) often presents alone or with a co-existing ductal carcinoma in situ component (IDC + DCIS). Studies have suggested that pure IDC may exhibit different biological behavior than IDC + DCIS, but whether this translates to a ...
A. Kole, Henry S. Park, Skyler B Johnson, J. Kelly, M. Moran, Abhijit A. Patel   +5 more
semanticscholar   +1 more source

Low-grade screen-detected ductal carcinoma in situ progresses more slowly than high-grade lesions:evidence from an international multi-centre study

, 2019
Nuclear grade is an important indicator of the biological behaviour of ductal carcinoma in situ (DCIS). De-escalation of treatment has been suggested for low-grade DCIS.
Fitzpatrick, Patricia, Ronco, G., Tomatis, M., Broeders, M., Hofvind, S., Majek, Ondrej, Frigerio, Alfonso, Bulliard, J.L., Ronco, Guglielmo, Segnan, Nereo, Ascunce, N., Ascunce, Nieves, Frigerio, A., Broeders, Mireille, Hofvind, Solveig, Castellano, Isabella, Segnan, N., Ponti, A., Taplin, S., Anttila, Ahti, Ponti, Antonio, Májek, O., Castellano, I., Bulliard, Jean-Luc, Taplin, Stephen, Lynge, E., Tomatis, Mariano, Lynge, Elsebeth, Fitzpatrick, P., Anttila, A.   +29 more
core   +1 more source

Breast Cancer Outcomes From Ductal Carcinoma In Situ: A Population‐Based Cohort Study

International Journal of Cancer, EarlyView.
Women with ductal carcinoma in situ have an elevated risk of subsequent invasive breast cancer, but how this risk evolves over time is unclear. In this population‐based study of ethnically diverse women diagnosed between 2000 and 2022 in New Zealand, the risk of invasive ipsilateral breast cancer persisted beyond 5 years.
Qian Chen, Ian Campbell, Mark Elwood, Alana Cavadino, Phyu Sin Aye, Sandar Tin Tin   +5 more
wiley   +1 more source

Molecular Evaluation of Breast Ductal Carcinoma in Situ with Oncotype DX DCIS.

American Journal of Pathology, 2019
A subset of patients with ductal carcinoma in situ (DCIS) of the breast develop ipsilateral invasive breast cancer after breast-conserving surgery with or without adjuvant radiotherapy.
S. Nofech-Mozes, W. Hanna, E. Rakovitch
semanticscholar   +1 more source

LncRNA IPW inhibits growth of ductal carcinoma in situ by downregulating ID2 through miR-29c

Breast Cancer Research, 2022
Background Ductal carcinoma in situ (DCIS) of breast is the noninvasive lesion that has propensity to progress to the malignant form. At present, it is still unknown which lesions can potentially progress to invasive forms.
Ravindra Pramod Deshpande, Sambad Sharma, Yin Liu, Puspa Raj Pandey, Xinhong Pei, Kerui Wu, Shih-Ying Wu, Abhishek Tyagi, Dan Zhao, Yin-Yuan Mo, Kounosuke Watabe   +10 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Refined estimates of local recurrence risks by DCIS score adjusting for clinicopathological features: a combined analysis of ECOG-ACRIN E5194 and Ontario DCIS cohort studies

Breast Cancer Research and Treatment, 2018
PurposeBetter tools are needed to estimate local recurrence (LR) risk after breast-conserving surgery (BCS) for DCIS. The DCIS score (DS) was validated as a predictor of LR in E5194 and Ontario DCIS cohort (ODC) after BCS. We combined data from E5194 and
E. Rakovitch, R. Gray, F. Baehner, R. Sutradhar, M. Crager, S. Gu, S. Nofech-Mozes, S. Badve, W. Hanna, L. Hughes, W. Wood, N. Davidson, L. Paszat, S. Shak, J. Sparano, L. Solin   +15 more
semanticscholar   +1 more source

The Endocrine Disrupting Compounds Bisphenol‐A and α‐Zeranol Mimic the Estrogen Transcriptional Program to Promote Proliferation and Stemness in Breast Cancer Cells

Molecular Carcinogenesis, EarlyView.
ABSTRACT Excessive activation of the estrogen receptor (ER) drives proliferation, progression, and the formation of breast cancer stem cells (CSCs) in ER‐positive breast cancer. Estrogenic endocrine disrupting compounds (EDCs) found in plastics, water, and food are also able to bind to the ER.
Cassandra Winz, Eric Li, Caroline Xie, Kyo Chang Lee, Kevin Boguszewski, Shlok Rohatagi, Rita Hahn, Ray Rancourt, Philip Furmanski, Nanjoo Suh   +9 more
wiley   +1 more source

Surgical upstaging rates for vacuum assisted biopsy proven DCIS: implications for active surveillance trials

Annals of Surgical Oncology, 2017
PurposeThis study was designed to determine invasive cancer upstaging rates at surgical excision following vacuum-assisted biopsy of ductal carcinoma in situ (DCIS) among women meeting eligibility for active surveillance trials.MethodsPatients with ...
Mhs Lars J. Grimm MD, M. Ryser, Mph Ann H. Partridge MD, A. Thompson, J. S. T. Mbbs, PhD Jelle Wesseling MD, Mph E. Shelley Hwang MD   +6 more
semanticscholar   +1 more source