Results 71 to 80 of about 20,385 (185)

Application of deep learning on mammographies to discriminate between low and high-risk DCIS for patient participation in active surveillance trials

Cancer Imaging
Background Ductal Carcinoma In Situ (DCIS) can progress to invasive breast cancer, but most DCIS lesions never will. Therefore, four clinical trials (COMET, LORIS, LORETTA, AND LORD) test whether active surveillance for women with low-risk Ductal ...
Sena Alaeikhanehshir, Madelon M. Voets, Frederieke H. van Duijnhoven, Esther H. lips, Emma J. Groen, Marja C. J. van Oirsouw, Shelley E. Hwang, Joseph Y. Lo, Jelle Wesseling, Ritse M. Mann, Jonas Teuwen, Grand Challenge PRECISION Consortium Steering Group   +11 more
doaj   +1 more source

Simulation‐Based Assessment of Second‐Order Residual Stress Fields on the Fatigue Performance of Silicon‐Strengthened Ferritic Ductile Irons

Advanced Engineering Materials, Volume 28, Issue 6, 18 March 2026.
This work presents a simulation‐based framework based on representative volume elements (RVEs) that explicitly incorporates process‐induced second‐order residual stresses into the fatigue strength assessment of ductile cast iron (DCI). For the first time, this approach enables a direct evaluation of the influence of second‐order residual stress fields ...
Lutz Horbach, Xuemei Lyu, Jiali Zhang, Felix Weber, Christoph Broeckmann   +4 more
wiley   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, Volume 13, Issue 16, 18 March 2026.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ

BMC Cancer, 2018
Background Tumour-infiltrating lymphocytes (TILs) have been demonstrated to significantly influence prognosis and response to therapy of invasive breast cancer (IBC).
Marie Beguinot, Marie-Melanie Dauplat, Fabrice Kwiatkowski, Guillaume Lebouedec, Lucie Tixier, Christophe Pomel, Frederique Penault-Llorca, Nina Radosevic-Robin   +7 more
doaj   +1 more source

Are There Socio‐Demographic Inequalities in the Utilisation of Tumour and ctDNA Somatic Mutation Testing in Solid Tumours? A Systematic Review

Cancer Medicine, Volume 15, Issue 3, March 2026.
This systematic review investigates whether inequalities exist in the utilisation of tumour and ctDNA somatic mutation testing in solid tumours. The review concludes that, across tumour types, testing modalities and socio‐demographic factors, inequalities exist and require further exploration.
Sarah Rae, Annie Baldwin, Maria Julia Lagonera, Ruth Norris, Alastair Greystoke, Linda Sharp   +5 more
wiley   +1 more source

Multimodal genome-wide survey of progressing and non-progressing breast ductal carcinoma in-situ

Breast Cancer Research
Background Ductal carcinoma in-situ (DCIS) is a pre-invasive form of invasive breast cancer (IBC). Due to improved breast cancer screening, it now accounts for ~ 25% of all breast cancers. While the treatment success rates are over 90%, this comes at the
Marija Debeljak, Soonweng Cho, Bradley M. Downs, Michael Considine, Brittany Avin-McKelvey, Yongchun Wang, Phillip N. Perez, William E. Grizzle, Katherine A. Hoadley, Charles F. Lynch, Brenda Y. Hernandez, Paul J. van Diest, Wendy Cozen, Ann S. Hamilton, Debra Hawes, Edward Gabrielson, Ashley Cimino-Mathews, Liliana D. Florea, Leslie Cope, Christopher B. Umbricht   +19 more
doaj   +1 more source

Can Mammography and Magnetic Resonance Imaging Predict the Preoperative Size and Nuclear Grade of Pure Ductal Carcinoma In Situ?

Diagnostics
Background/Objectives: Thirty to fifty percent of ductal carcinoma in situ (DCIS) cases are high-grade and at risk of progressing to invasive carcinoma. The most important treatment-related risk factor for recurrence is the presence of residual DCIS. The
Hülya Çetin Tunçez, Merve Gürsoy Bulut, Zehra Hilal Adıbelli, Ahmet Bozer, Bülent Ahmet Kart, Demet Kocatepe Çavdar   +5 more
doaj   +1 more source

Identifying a highly-aggressive DCIS subgroup by studying intra-individual DCIS heterogeneity among invasive breast cancer patients.

PLoS ONE, 2014
The heterogeneity among multiple ductal carcinoma in situ (DCIS) lesions within the same patient also diagnosed with invasive ductal carcinoma (IDC) has not been well evaluated, leaving research implications of intra-individual DCIS heterogeneity yet to ...
Dana Pape-Zambito, Zhengyu Jiang, Hong Wu, Karthik Devarajan, Carolyn M Slater, Kathy Q Cai, Arthur Patchefsky, Mary B Daly, Xiaowei Chen   +8 more
doaj   +1 more source

Male Breast Cancer: Growing Insights and Continuing Challenges

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Breast cancer (BC) in men accounts for less than 1% of all BC diagnoses worldwide. Despite its low incidence, the number of men being diagnosed is increasing. Historically perceived as a predominantly female disease, BC in men has received comparatively limited attention.
Sahar Iftikhar, Elissa Burr, Amal Freigoun, Theo Nearney, Christelle Q. Kanda, Hazel Robinson, Caroline Vermeren, Udana Wickramaratne, Matthew Everest, Luca Foley, Valerie Speirs   +10 more
wiley   +1 more source

Breast Fibromatosis in a Patient With a History of Treated Breast Cancer: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Desmoid tumors are benign mesenchymal neoplasms that originate from muscular fasciae and aponeuroses. Breast involvement is exceptionally rare, accounting for less than 0.2% of all breast tumors. A 41‐year‐old woman with a history of right‐sided invasive ductal carcinoma (IDC) diagnosed in 2022 underwent breast‐conserving surgery (BCS) and ...
Saba Ebrahimian, Sakineh Soleimani Varaki, Faezeh Zabihi   +2 more
wiley   +1 more source