Results 101 to 110 of about 4,166 (290)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

open access: yesAdvanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang   +13 more
wiley   +1 more source

A microscopic field theoretical approach for active systems

open access: yesNew Journal of Physics, 2016
We consider a microscopic modeling approach for active systems. The approach extends the phase field crystal (PFC) model and allows us to describe generic properties of active systems within a continuum model.
F Alaimo, S Praetorius, A Voigt
doaj   +1 more source

Controlling Photochromism of Donor‐Acceptor Stenhouse Adducts on Micro‐Dot Arrays Beyond Human‐Eyes Resolution for Dynamic Light Encryption

open access: yesAdvanced Science, EarlyView.
This study presents a micro‐dot array strategy for dynamic light encryption, utilizing DASA‐based photochromism with resolution beyond human‐eye capacity. By precisely controlling isomerization kinetics, the method reveals multi‐layered encrypted information under specific light irradiation, enhancing information security and anti‐counterfeiting ...
Hongtao Hu   +10 more
wiley   +1 more source

A review of metal-ion-flux-controlled growth of metastable TiAlN by HIPIMS/DCMS co- sputtering A Review of Metal-ion-flux-controlled Growth of Metastable TiAlN by HIPIMS/DCMS Co-sputtering

open access: yes, 2020
We review results on the growth of metastable Ti1-xAlxN alloy films by hybrid high-power pulsed and dc magnetron co-sputtering (HIPIMS/DCMS) using the time domain to apply substrate bias either in synchronous with the entire HIPIMS pulse or just the ...
Grzegorz Greczynski   +14 more
core  

The contribution of culture to regeneration in the UK: a review of evidence: a report to the Department for Culture Media and Sport [PDF]

open access: yes, 2004
This review was commissioned by the Department for Culture Media and Sport (DCMS) to inform the preparation of a policy document on the contribution of cultural activity to regeneration.
Shaw, Phyllida   +2 more
core  

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma   +12 more
wiley   +1 more source

Mechanical properties of DCMS and HiPIMS deposited Ti1-xMoxB2±z coatings

open access: yes
A promising strategy for enhancing the mechanical properties of sputtered transition metal diboride (TMB2) thin films, including hardness and fracture toughness, is the formation of ternary diborides.
Gutschka, Christian; orcid:   +11 more
core   +1 more source

Astrocyte membrane properties are altered in a rat model of developmental cortical malformation but single-cell astrocytic glutamate uptake is robust

open access: yesNeurobiology of Disease, 2016
Developmental cortical malformations (DCMs) are linked with severe epilepsy and are caused by both genetic and environmental insults. DCMs include several neurological diseases, such as focal cortical dysplasia, polymicrogyria, schizencephaly, and others.
Elizabeth Hanson   +2 more
doaj   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

open access: yesAdvanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo   +7 more
wiley   +1 more source

Corrosion behaviour of post-deposition polished droplets-embedded arc evaporated and droplets-free HIPIMS/DCMS coatings

open access: yes, 2017
In this study, the effect of metal rich core of the droplets on the corrosion properties of TiN, CrN and ZrN arc evaporated nitride coatings has been investigated and the corrosion properties of such coatings have been compared with droplet free, highly ...
Yashodhan Purandare   +7 more
core   +1 more source

Home - About - Disclaimer - Privacy