Results 161 to 170 of about 3,123 (186)
Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance The Dcp2 decapping enzyme targets mRNA for degradation and thereby plays a role in the regulation of gene expression. Despite numerous static crystal structures of the enzyme, it remained unclear how its catalytic activity ...
Remco Sprangers, Jan Philip Wurm
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Structure of the Dcp2–Dcp1 mRNA-decapping complex in the activated conformation
Nature Structural and Molecular Biology, 2016 The removal of the mRNA 5' cap (decapping) by Dcp2 shuts down translation and commits mRNA to full degradation. Dcp2 activity is enhanced by activator proteins such as Dcp1 and Edc1.
Oliver Weichenrieder +2 more
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mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2 [PDF]
Molecular Cell, 2008 Cap hydrolysis by Dcp2 is a critical step in several eukaryotic mRNA decay pathways. Processing requires access to cap-proximal nucleotides and the coordinated assembly of a decapping mRNP, but the mechanism of substrate recognition and regulation by protein interactions have remained elusive.
Jacek Jemielity +2 more
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Nucleic Acids Research, 2014 The removal of the 5'-cap structure by the decapping enzyme DCP2 and its coactivator DCP1 shuts down translation and exposes the mRNA to 5'-to-3' exonucleolytic degradation by XRN1.
Elisa Izaurralde +2 more
exaly +2 more sources
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SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity
Biochemical and Biophysical Research Communications, 2008We identified human decapping enzyme 2 (hDCP2) as a binding protein with Ro52, being colocalized in processing bodies (p-bodies). We also showed that the N-terminus and C-terminus of Ro52 bound to hDCP2. Moreover, Ro52 enhanced decapping activity of hDCP2 in a dose-dependent manner. Our data support the novel notion of the association between Ro52 with
Tadanori, Yamochi +5 more
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Global deletion of the RNA decapping enzyme Dcp2 postnatally in male mice results in infertility
Biochemical and Biophysical Research Communications, 2020The post-transcriptional regulation of gene expression plays an important role in many essential biological processes. The RNA decapping enzyme Dcp2 is a crucial enzyme involved in RNA degradation. Dcp2 proteins are highly expressed in the testis and brain in adult mice. This study aimed to investigate the in vivo functions of Dcp2.
Rui-Min, Li +3 more
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Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia
Cell Biology and Toxicology, 2023RNA-binding proteins (RBPs), long non-coding RNAs (lncRNAs), and small nucleolar RNAs (snoRNAs) were found to play crucial regulatory roles in ischemic injury. Based on GEO databases and our experimental results, we selected Dcp2, lncRNA-RNCR3, Dkc1, and Snora62 and Foxh1 as research candidates.
Jin, Yang +11 more
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Diffuse Decapping Enzyme DCP2 Accumulates in DCP1 Foci Under Heat Stress in Arabidopsis thaliana
Plant and Cell Physiology, 2014The decapping enzymes DCP1 and DCP2 are components of a decapping complex that degrades mRNAs. DCP2 is the catalytic core and DCP1 is an auxiliary subunit. It has been assumed that DCP1 and DCP2 are consistently co-localized in cytoplasmic RNA granules called processing bodies (P-bodies).
Kazuki, Motomura +6 more
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Dynamics of DCP2 granules in pollen
Plant and Cell Physiology Supplement, 2009Fukaya, Takashi +3 more
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