Results 1 to 10 of about 967 (91)

Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways [PDF]

eLife
Degradation of many yeast mRNAs involves decapping by the Dcp1:Dcp2 complex. Previous studies on decapping activators Edc3 and Scd6 suggested their limited roles in mRNA decay.
Rakesh Kumar, Fan Zhang, Shreyas Niphadkar, Chisom Onu, Anil Kumar Vijjamarri, Miriam L Greenberg, Sunil Laxman, Alan G Hinnebusch   +7 more
doaj   +2 more sources

Roles of P-body factors in Candida albicans filamentation and stress response. [PDF]

PLoS Genetics
Hyphal growth is strongly associated with virulence in the human fungal pathogen Candida albicans. While hyphal transcriptional networks have been the subject of intense study, relatively little is known about post-transcriptional regulation.
Melissa A Tosiano, Frederick Lanni, Aaron P Mitchell, C Joel McManus   +3 more
doaj   +2 more sources

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay and its association to intellectual disability

BMC Medical Genomics, 2018
Background Decapping of mRNA is an important step in the regulation of mRNA turnover and therefore of gene expression, which is a key process controlling development and homeostasis of all organisms.
Arif Ekici, Steffen Uebe, André Reis
exaly   +3 more sources

A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4 [PDF]

Nature Communications
The interaction of host and Ebola virus (EBOV) proteins is required for establishing infection. In this study, we use proximity-dependent biotinylation to identify cellular proteins that bind to EBOV proteins encoded by six of the seven viral genes. Hits
Callie J. Donahue, Aditi S. Kesari, Naveen Thakur, Ling Wang, Sarah Hulsey Stubbs, Caroline G. Williams, Sandhya Bharti Sharma, Cara D. Kirby, Daisy W. Leung, Uma K. Aryal, Christopher F. Basler, Douglas J. LaCount, Robert A. Davey   +12 more
doaj   +2 more sources

Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis

Nature Communications, 2018
The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators.
Jacek Jemielity, John Gross, Ryan W Tibble   +2 more
exaly   +2 more sources

The EDC3 chronology for the EPICA Dome C ice core [PDF]

Climate of the Past, 2007
The EPICA (European Project for Ice Coring in Antarctica) Dome C drilling in East Antarctica has now been completed to a depth of 3260 m, at only a few meters above bedrock.
Valérie Masson-Delmotte, Hubertus Fischer, Renato Spahni   +2 more
exaly   +1 more source

Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes [PDF]

Epigenetics
Lung carcinogenesis is causally linked to cigarette smoking, in part by epigenetic changes. We tested whether accumulated epigenetic change in smokers is apparent in bronchial basal cells as cells of origin of squamous cell carcinoma.
Batbayar Khulan, Kenny Ye, Miao Kevin Shi, Spencer Waldman, Ava Marsh, Taha Siddiqui, Aham Okorozo, Aditi Desai, Dhruv Patel, Jay Dobkin, Ali Sadoughi, Chirag Shah, Shweta Gera, Yakov Peter, Will Liao, Jan Vijg, Simon D. Spivack   +16 more
doaj   +2 more sources

Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation [PDF]

Cell Chemical Biology, 2022
Adam Borne, Ku-lung Hsu, Heather A Ferris   +2 more
exaly   +2 more sources

Dcp2 C-terminal cis-binding elements control selective targeting of the decapping enzyme by forming distinct decapping complexes

eLife, 2022
A single Dcp1–Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5′ to 3′ decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Feng He, Chan Wu, Allan Jacobson
doaj   +1 more source

Assay to Study the Phase-transition Behavior of Edc3, a Conserved Processing Body (P-body) Marker Protein

Bio-Protocol, 2022
RNA granules are conserved, non-membranous, biphasic structures predominantly composed of RNA and RNA-binding proteins. RNA granules often assemble as a result of cellular responses to a variety of stresses, including infection. Two types of RNA granules
Raju Roy, Purusharth Rajyaguru
doaj   +1 more source