Results 31 to 40 of about 1,370 (154)

Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

eLife, 2023
Degradation of most yeast mRNAs involves decapping by Dcp1/Dcp2. DEAD-box protein Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to enhanced degradation, and as a translational repressor, but its functions in ...
Anil Kumar Vijjamarri, Xiao Niu, Matthew D Vandermeulen, Chisom Onu, Fan Zhang, Hongfang Qiu, Neha Gupta, Swati Gaikwad, Miriam L Greenberg, Paul J Cullen, Zhenguo Lin, Alan G Hinnebusch   +11 more
doaj   +1 more source

Atomic-level insight into mRNA processing bodies by combining solid and solution-state NMR spectroscopy

Nature Communications, 2019
Processing bodies are membrane less organelles that contain enzymes involved in mRNA turnover, among them enhancer of decapping 3 (Edc3). Here the authors use solid- and solution-state NMR spectroscopy to characterize the structural organization and ...
Reinier Damman, Stefan Schütz, Yanzhang Luo, Markus Weingarth, Remco Sprangers, Marc Baldus   +5 more
doaj   +1 more source

The C-terminal domain from S. cerevisiae Pat1 displays two conserved regions involved in decapping factor recruitment. [PDF]

PLoS ONE, 2014
Eukaryotic mRNA decay is a highly regulated process allowing cells to rapidly modulate protein production in response to internal and environmental cues.
Zaineb Fourati, Olga Kolesnikova, Régis Back, Jenny Keller, Clément Charenton, Valerio Taverniti, Claudine Gaudon Plesse, Noureddine Lazar, Dominique Durand, Herman van Tilbeurgh, Bertrand Séraphin, Marc Graille   +11 more
doaj   +1 more source

A comparison of the present and last interglacial periods in six Antarctic ice cores [PDF]

Climate of the Past, 2011
We compare the present and last interglacial periods as recorded in Antarctic water stable isotope records now available at various temporal resolutions from six East Antarctic ice cores: Vostok, Taylor Dome, EPICA Dome C (EDC), EPICA Dronning Maud Land (
V. Masson-Delmotte, D. Buiron, A. Ekaykin, M. Frezzotti, H. Gallée, J. Jouzel, G. Krinner, A. Landais, H. Motoyama, H. Oerter, K. Pol, D. Pollard, C. Ritz, E. Schlosser, L. C. Sime, H. Sodemann, B. Stenni, R. Uemura, F. Vimeux   +18 more
doaj   +1 more source

Phosphorylation of an RNA-Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging. [PDF]

Aging Cell
Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Yeom E, Mun H, Lim J, Chun YL, Min KW, Lambert J, Cowart LA, Pierce JS, Ogretmen B, Cho JH, Chang JH, Buchan JR, Pitt J, Kaeberlein M, Kang SU, Kwon ES, Ko S, Choi KM, Lee YS, Ha YS, Kim SJ, Lee KP, Kim HS, Yang SY, Shin CH, Yoon JH, Lee KS.   +26 more
europepmc   +2 more sources

EDC3: Ensemble of Deep-Classifiers using Class-specific Copula functions to Improve Semantic Image Segmentation

CoRR, 2020
In the literature, many fusion techniques are registered for the segmentation of images, but they primarily focus on observed output or belief score or probability score of the output classes. In the present work, we have utilized inter source statistical dependency among different classifiers for ensembling of different deep learning techniques for ...
Somenath Kuiry, Nibaran Das, Alaka Das, Mita Nasipuri   +3 more
openaire   +3 more sources

Towards orbital dating of the EPICA Dome C ice core using δO₂/N₂ [PDF]

Climate of the Past, 2012
Based on a composite of several measurement series performed on ice samples stored at −25 °C or −50 °C, we present and discuss the first δO2/N2 record of trapped air from the EPICA Dome C (EDC) ice core covering the period between 300 and 800 ka ...
J. Jouzel, L. Arnaud, V. Masson-Delmotte, D. Paillard, D. Raynaud, V. Y. Lipenkov, M. F. Loutre, K. Pol, E. Capron, G. Dreyfus, A. Landais, M. Leuenberger   +11 more
doaj   +1 more source

Genome-wide assessment and mapping of inbreeding depression identifies candidate genes associated with semen traits in Holstein bulls

BMC Genomics, 2023
Background The reduction in phenotypic performance of a population due to mating between close relatives is called inbreeding depression. The genetic background of inbreeding depression for semen traits is poorly understood.
Mohammad Ghoreishifar, Seyed Milad Vahedi, Siavash Salek Ardestani, Majid Khansefid, Jennie E. Pryce   +4 more
doaj   +1 more source

"EDML1": a chronology for the EPICA deep ice core from Dronning Maud Land, Antarctica, over the last 150 000 years [PDF]

Climate of the Past, 2007
A chronology called EDML1 has been developed for the EPICA ice core from Dronning Maud Land (EDML). EDML1 is closely interlinked with EDC3, the new chronology for the EPICA ice core from Dome-C (EDC) through a stratigraphic match between EDML and EDC ...
U. Ruth, J.-M. Barnola, J. Beer, M. Bigler, T. Blunier, E. Castellano, H. Fischer, F. Fundel, P. Huybrechts, P. Kaufmann, S. Kipfstuhl, A. Lambrecht, A. Morganti, H. Oerter, F. Parrenin, O. Rybak, M. Severi, R. Udisti, F. Wilhelms, E. Wolff   +19 more
doaj  

Phosphorylation of mRNA decapping protein Dcp1a by the ERK signaling pathway during early differentiation of 3T3-L1 preadipocytes.

PLoS ONE, 2013
BackgroundTurnover of mRNA is a critical step in the regulation of gene expression, and an important step in mRNA decay is removal of the 5' cap. We previously demonstrated that the expression of some immediate early gene mRNAs is controlled by RNA ...
Pei-Yu Chiang, Yu-Fang Shen, Yu-Lun Su, Ching-Han Kao, Nien-Yi Lin, Pang-Hung Hsu, Ming-Daw Tsai, Shun-Chang Wang, Geen-Dong Chang, Sheng-Chung Lee, Ching-Jin Chang   +10 more
doaj   +1 more source