Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma [PDF]
Journal of Translational MedicineBackground Patients with glioblastoma (GBM) have a poor prognosis and limited treatment options. The mRNA decapping enzyme scavenger (DCPS) is a cap-hydrolyzing enzyme.
Yonggao Mou, Hao Duan, Hongrong Hu
exaly +4 more sources
Creatine mitigates neurogenesis impairment caused by defective DcpS decapping [PDF]
Scientific ReportsBiallelic mutations in the DCPS gene disrupting the decapping activity of the scavenger decapping protein DcpS, leads to neurodevelopmental deficiencies and intellectual disability.
Megerditch Kiledjian, Ronald P. Hart
exaly +3 more sources
Integrated FHIT and IDH2 biomarker profiling predicts lethal sensitivity to DCPS inhibition in Acute Myeloid Leukemia and Myelodysplastic syndrome [PDF]
Discover OncologyBackground/objectives Development of novel therapies for acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) is hindered by limited biomarkers to identify appropriate target populations and poor translatability of preclinical drug candidates.
Francesca Grassi +7 more
doaj +2 more sources
Liquid–liquid phase separation and the formation of amyloid fibrils from DcpS scavenger enzymes [PDF]
Scientific ReportsDecapping Scavenger (DcpS) enzyme was initially identified by its ability to hydrolyze the cap structure resulting from mRNA decay. Human DcpS is an established target for acute myeloid leukemia (AML) and hepatic metastasis.
Aleksandra Ferenc-Mrozek +6 more
doaj +2 more sources
Genetic Characteristics and Preservative Tolerance of Spoilage Microorganisms in Daily Chemical Products [PDF]
MicroorganismsDaily chemical products (DCPs), including cosmetics and cleaning products, are widely used in everyday life but are vulnerable to microbial contamination during production, storage, and use.
Xia Wen +8 more
doaj +2 more sources
A survey on providers’ views on utilization of dental hygienists and dental therapists delivering periodontal care in the South West of England [PDF]
BDJ OpenAim To examine the opportunities and limitations for dental hygienists and therapists (DCPs) delivering periodontal care in primary care settings. Materials and Methods A cross-sectional survey was conducted among primary care dental providers in the ...
Cher Farrugia +3 more
doaj +2 more sources
European Journal of Spatial Development, 2023 Even when they have access to housing and employment, international migrants struggle to develop their own agency, i.e. the capacity to act in their own life contexts, exercising citizenship rights within substantive inclusion processes in the wider ...
Andrea Membretti +3 more
doaj +11 more sources
In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: Context-specific modulation of SMN transcript levels [PDF]
PLoS ONE, 2017 C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS (DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), which is caused by genetic deficiency in the Survival Motor Neuron (SMN) protein ...
Christine J DiDonato +2 more
exaly +2 more sources
Selective Targeting and Enhanced Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus (MRSA) by a Decacationic Vancomycin–Mesochlorin Conjugate [PDF]
AntibioticsBackground/Objectives: Covalent conjugation of an antibiotic vancomycin (VCM) moiety and a photosensitizing mesochlorin (mChlPd) unit into one molecular entity may present the potential to produce the combinatorial effect of both antibacterial ...
He Yin +5 more
doaj +2 more sources
Informed Consent for Newborn Genomic Screening: Interest-Holder Perspectives on Dynamic Consent in an Evolving Landscape [PDF]
International Journal of Neonatal ScreeningNewborn Bloodspot Screening (NBS) has significantly advanced early disease detection, preventing severe disability and infant mortality. The anticipated integration of genomic technologies into NBS (gNBS) promises earlier diagnosis and targeted ...
Marina Okamura +5 more
doaj +2 more sources