Results 21 to 30 of about 2,927 (248)

DcpS as a Therapeutic Target for Spinal Muscular Atrophy

, 2016
Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene, which produces an essential protein known as SMN. The severity of SMA is modified by variable copy number of a second gene, SMN2, which produces an mRNA that
Jill Jarecki (2407498), Megerditch Kiledjian (2407492), John Thurmond (2407504), Dawn R. Mattoon (2407495), Lance Stewart (2159074), Mark E. Gurney (1266966), Michael Salcius (308345), John Printen (2407486), Bart L. Staker (244387), Jon Mar Bjornsson (2391301), Shin-Wu Liu (2407483), Gregory Michaud (151061), Rama Mishra (1266945), Jasbir Singh (677393), Jeffery Christensen (2407489), Brian A. Pollok (2407501)   +15 more
core   +2 more sources

Spanning the Globe – The Plant Phylogeny Poster (PPP) Project

Ukrainian Botanical Journal, 2021
Historically, wallcharts and posters created by botanical illustrators, often highly skilled artists, have played an important role in teaching botany at the university level.
Cole T.C.H., Hilger H.H., Bachelier J.B., Stevens P.F., Goffinet B., Shiyan N.M., Zhygalova S.L., Mosyakin S.L.   +7 more
doaj   +1 more source

Functional analysis of DcpS as a candidate cutaneous squamous cell carcinoma susceptibility gene [PDF]

, 2012
DCPS is a candidate cutaneous squamous cell carcinoma (SCC) susceptibility gene as determined by allelic imbalance mapping of paired SCC and genomic blood DNA samples.
Gray, Kelsey
core   +1 more source

The performance of the digital city projects in urban studies of the megalopolises (the case studies of Kharkiv and Dnipro cities)

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Геологія. Географія. Екологія, 2023
Introduction of the research problem. Urbanization drives Digital City Projects (DCPs) to create smarter urban environments using advanced technologies. DCPs aim to make cities more connected and responsive, adapting to changing needs.
Sergiy Kostrikov, Kateryna Kravchenko, Denys Serohin, Sofiia Bilianska, Anastasia Savchenko   +4 more
doaj   +1 more source

Speak up DCPs!

, 2009
Why do many DCPs still struggle for recognition, status and remuneration?
Debbie Reed, Reed, Debbie
core   +1 more source

The equivalence in the DCP model

Theoretical Computer Science, 1991
The importance of equivalence relation (on processes) defined in algebraic theories of processes (like CCS, CSP, DCP, etc.) is well known. This paper deals with the equivalence relation in the DCP model. After a brief overview of some equivalences on labelled transitions systems and the relations between them, the authors, in order to find the place of
Reine Fournier, Gregor von Bochmann
openaire   +2 more sources

Patients’ and clinicians’ perspectives on telemedicine to monitor patients on systemic treatment for psoriasis or atopic dermatitis - a mixed methods study

Journal of Dermatological Treatment
Background For patients with stable psoriasis or atopic dermatitis (AD) receiving systemic treatment, telemedicine may offer a viable alternative to in-person consultations. However, perspectives of these patients and dermatological care providers (DCPs)
Nikki F. T. Henckens, Marta E. Pawlak, Sophie A. C. Wanten, Ying C. Weng, Ilse v. Ee, Bernd W. M. Arents, Leonard Witkamp, Marjolein S. de Bruin-Weller, Ewout M. Baerveldt, Marieke M. B. Seyger, Elke M. G. J. de Jong, Wynanda A. van Enst, Juul M. P. A. van den Reek   +12 more
doaj   +1 more source

Structural and functional studies of the Scavenger Decapping Enzyme DcpS: Untersuchungen zur Struktur und Funktion des Scavenger Decapping Enzyms DcpS

, 2019
Messenger RNA (mRNA) is the working copy of a gene containing the information for the production of a specific protein. The amount of any given protein has to be adjusted to the current needs of a cell.
Fuchs, A. ; https://orcid.org/
core   +1 more source

Molecular basis of the selective processing of short mRNA substrates by the DcpS mRNA decapping enzyme

, 2020
The 5' messenger RNA (mRNA) cap structure enhances translation and protects the transcript against exonucleolytic degradation. During mRNA turnover, this cap is removed from the mRNA.
Fuchs, Anna-Lisa, Sprangers, Remco, Sprangers, R., Wurm, J. ; https://orcid.org/, Fuchs, A. ; https://orcid.org/, Neu, A., Wurm, Jan Philip, Neu, Ancilla   +7 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source