Results 11 to 20 of about 55,550 (98)

β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain [PDF]

Molecules, 2019
Neuropathic pain associated with nucleoside reverse transcriptase inhibitors (NRTIs), therapeutic agents for human immunodeficiency virus (HIV), responds poorly to available drugs.
E. Aly, Maitham A. Khajah, W. Masocha
semanticscholar   +2 more sources

NICER observations reveal that the X-ray transient MAXI J1348−630 is a black hole X-ray binary [PDF]

, 2020
We studied the outburst evolution and timing properties of the recently discovered X-ray transient MAXI J1348-630 as observed with NICER. We produced the fundamental diagrams commonly used to trace the spectral evolution, and power density spectra to ...
Liang Zhang, D. Altamirano, V. Cúneo, V. Cúneo, K. Alabarta, K. Alabarta, T. Enoto, J. Homan, R. Remillard, P. Uttley, F. Vincentelli, Z. Arzoumanian, P. Bult, K. Gendreau, C. Markwardt, A. Sanna, T. Strohmayer, J. Steiner, A. Basak, J. Neilsen, F. Tombesi   +20 more
semanticscholar   +1 more source

Measuring the distance to the black hole candidate X-ray binary MAXI J1348–630 using H i absorption [PDF]

Monthly Notices of the Royal Astronomical Society: Letters, 2020
We present neutral hydrogen (H i) absorption spectra of the black hole candidate X-ray binary (XRB) MAXI J1348–630 using the Australian Square Kilometre Array Pathfinder (ASKAP) and MeerKAT.
J. Chauhan, J. Miller-Jones, W. Raja, J. Allison, P. Jacob, G. Anderson, F. Carotenuto, S. Corbel, R. Fender, A. Hotan, M. Whiting, P. Woudt, B. Koribalski, E. Mahony   +13 more
semanticscholar   +1 more source

Discovery of the Black Hole X-Ray Binary Transient MAXI J1348–630

Astrophysical Journal, 2020
We report the first half-year monitoring of the new Galactic black hole candidate MAXI J1348–630, discovered on 2019 January 26 with the Gas Slit Camera on board the Monitor of All-sky X-ray Image (MAXI).
M. Tominaga, S. Nakahira, M. Shidatsu, M. Oeda, K. Ebisawa, Y. Sugawara, H. Negoro, N. Kawai, M. Sugizaki, Y. Ueda, T. Mihara   +10 more
semanticscholar   +1 more source

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

Acta Neuropathologica
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response.
J. Rutledge, B. Lehallier, Pardis Zarifkar, P. M. Losada, M. Shahid-Besanti, D. Western, P. Gorijala, S. Ryman, M. Yutsis, Gayle K. Deutsch, Elizabeth C. Mormino, A. Trelle, Anthony D. Wagner, G. Kerchner, Lu Tian, C. Cruchaga, V. Henderson, T. Montine, P. Borghammer, T. Wyss‐Coray, K. Poston   +20 more
semanticscholar   +1 more source

STRING 8—a global view on proteins and their functional interactions in 630 organisms

Nucleic Acids Res., 2008
Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation.
L. Jensen, Michael Kuhn, M. Stark, Samuel Chaffron, C. Creevey, J. Muller, T. Doerks, P. Julien, Alexander C. J. Roth, M. Simonovic, P. Bork, C. V. Mering   +11 more
semanticscholar   +1 more source

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

International Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki, Maria Papatsirou, Michaela A. Boti, P. Adamopoulos, S. Christodoulou, D. Vassilacopoulou, A. Scorilas, C. Kontos   +7 more
semanticscholar   +1 more source

L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors

International Journal of Molecular Sciences, 2020
A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system.
E. Tremmel, C. Kuhn, T. Kaltofen, T. Vilsmaier, D. Mayr, S. Mahner, N. Ditsch, U. Jeschke, A. Vattai   +8 more
semanticscholar   +1 more source

CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630

Aging, 2017
Although CircRNA_100269 is a biomarker used to predict cancer recurrence, its expression and function in gastric cancer (GC) remain unknown. In this study, the expression of circRNA_100269 and its potential downstream miRNA targets were investigated. The
Yan Zhang, Hao Liu, Wende Li, Jiang Yu, Jin Li, Z. Shen, G. Ye, Xiaolong Qi, Guoxin Li   +8 more
semanticscholar   +1 more source

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Toxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis, J. Schenkel, M. Herzog, Tim Schellenberg, H. Jahr, T. Pufe, C. Trautwein, T. Kensler, K. Streetz, C. Wruck   +9 more
semanticscholar   +1 more source